SCNN1A and HECW1

Number of citations of the paper that reports this interaction (PubMedID 11244092)
46

Data Source:
BioGRID (far western blotting)

		SCNN1A	HECW1
Description		sodium channel epithelial 1 subunit alpha	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane Motile Cilium Sodium Channel Complex Ciliary Membrane Extracellular Exosome Sperm Principal Piece	Cytoplasm Cytosol
	Molecular Function	Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding	Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Sodium Ion Transmembrane Transport Multicellular Organismal Water Homeostasis Response To Stimulus Sensory Perception Of Taste Sodium Ion Homeostasis	Protein Polyubiquitination Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Dendrite Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Stimuli-sensing channels	Degradation of DVL
Drugs		Triamterene Amiloride
Diseases
GWAS		Adverse response to drug ( 30420678) Alopecia areata ( 25608926) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Obesity (early onset extreme) ( 23563609) Primary biliary cirrhosis ( 22961000) Spleen volume ( 34128465)	Alzheimer's disease (cognitive decline) ( 23535033) Bone mineral density (Ward's triangle area) ( 27397699) Caudal anterior-cingulate cortex volume ( 31530798) Cerebrospinal fluid AB1-42 levels ( 26252872) Delirium ( 29631748) Diverticular disease ( 28585551) Irritable bowel syndrome ( 29673008) Lung cancer in ever smokers ( 28604730) Mercury levels ( 26025379) Obesity-related traits ( 23251661) Serum galactose-deficient IgA1 levels ( 28187132) Type 2 diabetes ( 25102180)
Interacting Genes		18 interacting genes: COMMD10 CSNK2A1 EPN1 HECW1 ITCH NEDD4 NEDD4L NPC2 SCNN1B SCNN1G SERP1 SNX3 STX1A TSG101 UBE2I USP10 WWP1 WWP2	19 interacting genes: CACNA1A DVL1 GFI1B PRRG4 SCNN1A SCNN1B SHANK3 SSR4 TNK2 TP53 TSC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2J2 UBE2L3 USP7 VAX1
Entrez ID		6337	23072
HPRD ID		02575	11385
Ensembl ID		ENSG00000111319	ENSG00000002746
Uniprot IDs		P37088	Q76N89
PDB IDs		2M3O 6BQN 6WTH	3L4H
Enriched GO Terms of Interacting Partners?
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