SNX3 and RAB7A

Number of citations of the paper that reports this interaction (PubMedID 24344282)
53

Data Source:
BioGRID (pull down)

		SNX3	RAB7A
Description		sorting nexin 3	RAB7A, member RAS oncogene family
Image
GO Annotations	Cellular Component	Cytoplasm Early Endosome Cytosol Endosome Membrane Clathrin-coated Vesicle Retromer Complex Early Endosome Membrane Early Phagosome Extracellular Exosome	Autophagosome Membrane Lysosome Lysosomal Membrane Late Endosome Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Late Endosome Membrane Extrinsic Component Of Lysosome Membrane Melanosome Membrane Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Protein Binding Phosphatidylinositol-5-phosphate Binding Protein Phosphatase Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding Retromer Complex Binding	GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding Retromer Complex Binding
	Biological Process	Response To Bacterium Membrane Invagination Positive Regulation Of Neuron Projection Development Protein Transport Protein To Membrane Docking Regulation Of Wnt Signaling Pathway Endocytic Recycling Late Endosome To Golgi Transport Negative Regulation Of Protein Catabolic Process Negative Regulation Of Viral Entry Into Host Cell Negative Regulation Of Phagocytosis Negative Regulation Of Protein Transport Intralumenal Vesicle Formation Negative Regulation Of Early Endosome To Late Endosome Transport	Autophagosome Assembly Protein Targeting To Lysosome Endocytosis Epidermal Growth Factor Catabolic Process Endosome To Lysosome Transport Protein Transport Lipid Catabolic Process Viral Release From Host Cell Protein To Membrane Docking Retrograde Transport, Endosome To Golgi Early Endosome To Late Endosome Transport Positive Regulation Of Protein Catabolic Process Positive Regulation Of Viral Process Lipophagy Phagosome Maturation Phagosome Acidification Phagosome-lysosome Fusion Endosome To Plasma Membrane Protein Transport Multi-organism Intercellular Transport Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Negative Regulation Of Intralumenal Vesicle Formation
Pathways		WNT ligand biogenesis and trafficking Ub-specific processing proteases	MHC class II antigen presentation Neutrophil degranulation TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle Prevention of phagosomal-lysosomal fusion Suppression of autophagy
Drugs		S,S-(2-Hydroxyethyl)Thiocysteine	Guanosine-5'-Diphosphate
Diseases
GWAS			Body fat mass ( 28552196) Facial morphology traits (63 three-dimensional facial segments) ( 29459680)
Interacting Genes		12 interacting genes: ARL6IP1 BARD1 BRCA1 LIG4 PAXIP1 RAB7A RPRM SCNN1A STX11 TSC22D2 USP10 VPS35	35 interacting genes: CHM COPG1 ENOPH1 FABP6 GP9 H1-10 KRTAP10-3 KRTAP10-9 PPP2R1A PPP2R1B PRKN RAB13 RAB17 RAB22A RAB4A RAB4B RAB6A RABAC1 RABGGTB RILP RNF115 RPN1 SLC2A4 SNX3 TMCC1 TP53 UCHL5 VPS11 VPS16 VPS18 VPS26A VPS29 VPS39 VPS41 ZHX2
Entrez ID		8724	7879
HPRD ID		09333	03805
Ensembl ID		ENSG00000112335	ENSG00000075785
Uniprot IDs		O60493	A0A158RFU6 P51149
PDB IDs		2MXC 2YPS 5F0J 5F0L 5F0M 5F0P	1T91 1YHN 3LAW 6IYB 6WCW
Enriched GO Terms of Interacting Partners?
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