HECW1 and UBE2J2

Number of citations of the paper that reports this interaction (PubMedID 26949039)
64

Data Source:
BioGRID (pull down)

		HECW1	UBE2J2
Description		HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	ubiquitin conjugating enzyme E2 J2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol	Ubiquitin Ligase Complex Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Integral Component Of Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Activity	Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Dendrite Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Sodium Ion Transmembrane Transporter Activity	Protein Polyubiquitination Response To Unfolded Protein Ubiquitin-dependent ERAD Pathway Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Degradation of DVL	E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Bone mineral density (Ward's triangle area) ( 27397699) Caudal anterior-cingulate cortex volume ( 31530798) Cerebrospinal fluid AB1-42 levels ( 26252872) Delirium ( 29631748) Diverticular disease ( 28585551) Irritable bowel syndrome ( 29673008) Lung cancer in ever smokers ( 28604730) Mercury levels ( 26025379) Obesity-related traits ( 23251661) Serum galactose-deficient IgA1 levels ( 28187132) Type 2 diabetes ( 25102180)	Inflammatory bowel disease ( 28067908) Systemic lupus erythematosus ( 28714469) Ulcerative colitis ( 28067908)
Interacting Genes		19 interacting genes: CACNA1A DVL1 GFI1B PRRG4 SCNN1A SCNN1B SHANK3 SSR4 TNK2 TP53 TSC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2J2 UBE2L3 USP7 VAX1	22 interacting genes: AQP6 ATP13A2 ELOVL7 FBXO7 HECW1 HERC4 ITCH MDM2 MGRN1 NEDD4L PRKN PUSL1 RBP1 RNF10 TMEM14B TRIM25 TRIM59 UBA1 UBC UBE2G2 WWP2 XIAP
Entrez ID		23072	118424
HPRD ID		11385	15600
Ensembl ID		ENSG00000002746	ENSG00000160087
Uniprot IDs		Q76N89	A0A024R075 A6NGS0 Q8N2K1
PDB IDs		3L4H	2F4W
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?