RRM2 and ASAP2

		RRM2	ASAP2
Description		ribonucleotide reductase regulatory subunit M2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Ribonucleoside-diphosphate Reductase Complex	Plasma Membrane Golgi Cisterna Membrane
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Ferric Iron Binding Protein Homodimerization Activity	GTPase Activator Activity Protein Binding Metal Ion Binding
	Biological Process	Blastocyst Development DNA Replication Deoxyribonucleotide Biosynthetic Process Protein Heterotetramerization	Positive Regulation Of GTPase Activity
Pathways		Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription Transcriptional Regulation by E2F6
Drugs		Cladribine Imexon Gallium nitrate Motexafin gadolinium GTI 2040
Diseases
GWAS		Kidney function decline traits ( 25493955) Prostate cancer ( 23535732)	Bipolar disorder ( 31043756) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic obstructive pulmonary disease ( 30804561) Chronic widespread musculoskeletal pain ( 33331911) Pulse pressure ( 27841878 30578418) Urate levels ( 31578528)
Interacting Genes		19 interacting genes: ASAP2 BARX1 CDH1 CDK1 DNM1L GCG ITSN2 KAT5 LAPTM4A LPIN1 MGAT4A NPBWR2 PLK3 RRM1 RRM2B SDCBP ST3GAL3 TAF1B TP53	15 interacting genes: APC ARF1 ARF5 ARF6 BIN1 GRB2 ITSN1 PACSIN3 PTK2B PXN RAN REPS2 RRM2 SH3KBP1 THSD7A
Entrez ID		6241	8853
HPRD ID		01587	04820
Ensembl ID		ENSG00000171848	ENSG00000151693
Uniprot IDs		P31350	O43150
PDB IDs		2UW2 3OLJ 3VPM 3VPN 3VPO
Enriched GO Terms of Interacting Partners?
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