RRM2 and RRM1

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		RRM2	RRM1
Description		ribonucleotide reductase regulatory subunit M2	ribonucleotide reductase catalytic subunit M1
Image
GO Annotations	Cellular Component	Cytosol Ribonucleoside-diphosphate Reductase Complex	Nuclear Envelope Cytosol Ribonucleoside-diphosphate Reductase Complex Cell Projection Neuronal Cell Body
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Ferric Iron Binding Protein Homodimerization Activity	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding ATP Binding Identical Protein Binding Ribonucleoside-diphosphate Reductase Activity Disordered Domain Specific Binding
	Biological Process	Blastocyst Development DNA Replication Deoxyribonucleotide Biosynthetic Process Protein Heterotetramerization	Mitotic Cell Cycle Pyrimidine Nucleobase Metabolic Process DNA Replication Male Gonad Development Deoxyribonucleotide Biosynthetic Process Response To Ionizing Radiation Cell Proliferation In Forebrain Protein Heterotetramerization Retina Development In Camera-type Eye
Pathways		Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription Transcriptional Regulation by E2F6	Interconversion of nucleotide di- and triphosphates
Drugs		Cladribine Imexon Gallium nitrate Motexafin gadolinium GTI 2040	Cladribine Gemcitabine Clofarabine Hydroxyurea Fludarabine Imexon Gallium maltolate Tezacitabine
Diseases
GWAS		Kidney function decline traits ( 25493955) Prostate cancer ( 23535732)	Malaria ( 31844061) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 27863252 28957414)
Interacting Genes		19 interacting genes: ASAP2 BARX1 CDH1 CDK1 DNM1L GCG ITSN2 KAT5 LAPTM4A LPIN1 MGAT4A NPBWR2 PLK3 RRM1 RRM2B SDCBP ST3GAL3 TAF1B TP53	22 interacting genes: BMI1 CDC42 CUZD1 LRIF1 NUP98 PPP1CC PSMD13 RGS4 RNF2 RNH1 RRM2 RRM2B SH2D3A SIRPA SLC22A18 SLC22A18AS SPINK1 STIM1 SUMO2 YWHAG ZFPM2 ZNF655
Entrez ID		6241	6240
HPRD ID		01587	01588
Ensembl ID		ENSG00000171848	ENSG00000167325
Uniprot IDs		P31350	B4DXD1 B4E0I8 E9PL69 P23921
PDB IDs		2UW2 3OLJ 3VPM 3VPN 3VPO	2WGH 3HNC 3HND 3HNE 3HNF 4X3V 5D1Y 5TUS 6AUI 6L3R 6L7L 6LKM
Enriched GO Terms of Interacting Partners?
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