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ALX4 and LEF1
Number of citations of the paper that reports this interaction (PubMedID
11696550
)
13
Data Source:
HPRD
(in vitro)
ALX4
LEF1
Description
ALX homeobox 4
lymphoid enhancer binding factor 1
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Protein-DNA Complex
Beta-catenin-TCF Complex
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Protein Binding
HMG Box Domain Binding
Sequence-specific Double-stranded DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Beta-catenin Binding
DNA Binding, Bending
Estrogen Receptor Binding
Histone Binding
Histone Deacetylase Binding
Sequence-specific DNA Binding
Gamma-catenin Binding
Armadillo Repeat Domain Binding
C2H2 Zinc Finger Domain Binding
Transcription Regulator Inhibitor Activity
Sequence-specific Double-stranded DNA Binding
Biological Process
Skeletal System Development
Hair Follicle Development
Regulation Of Transcription By RNA Polymerase II
Muscle Organ Development
Post-embryonic Development
Anterior/posterior Pattern Specification
Embryonic Forelimb Morphogenesis
Embryonic Hindlimb Morphogenesis
Embryonic Digit Morphogenesis
Regulation Of Apoptotic Process
Positive Regulation Of Transcription By RNA Polymerase II
Digestive Tract Development
Embryonic Skeletal System Morphogenesis
Roof Of Mouth Development
Negative Regulation Of Transcription By RNA Polymerase II
Branching Involved In Blood Vessel Morphogenesis
Osteoblast Differentiation
Somitogenesis
Epithelial To Mesenchymal Transition
Sprouting Angiogenesis
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Positive Regulation Of Epithelial To Mesenchymal Transition
Dentate Gyrus Development
Forebrain Radial Glial Cell Differentiation
Forebrain Neuroblast Division
Formation Of Radial Glial Scaffolds
Positive Regulation Of Wnt Signaling Pathway
Neutrophil Differentiation
Embryonic Limb Morphogenesis
Positive Regulation Of Cell Migration
BMP Signaling Pathway
Positive Regulation Of Granulocyte Differentiation
Mammary Gland Development
Negative Regulation Of Interleukin-13 Production
Negative Regulation Of Interleukin-4 Production
Negative Regulation Of Interleukin-5 Production
T Cell Receptor V(D)J Recombination
B Cell Proliferation
Odontogenesis Of Dentin-containing Tooth
Negative Regulation Of Apoptotic Process
Negative Regulation Of DNA Binding
Tongue Development
Positive Regulation By Host Of Viral Transcription
Histone H3 Acetylation
Histone H4 Acetylation
T-helper 1 Cell Differentiation
Positive Regulation Of Gamma-delta T Cell Differentiation
Negative Regulation Of Striated Muscle Tissue Development
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Paraxial Mesoderm Formation
Sensory Perception Of Taste
Anatomical Structure Regression
Canonical Wnt Signaling Pathway
Face Morphogenesis
Cell Chemotaxis
Chorio-allantoic Fusion
Trachea Gland Development
Secondary Palate Development
Cellular Response To Cytokine Stimulus
Cellular Response To Interleukin-4
Positive Regulation Of Cell Proliferation In Bone Marrow
Negative Regulation Of Apoptotic Process In Bone Marrow Cell
Histone H3-K56 Acetylation
Apoptotic Process Involved In Blood Vessel Morphogenesis
Positive Regulation Of Chondrocyte Proliferation
Pathways
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex
Ca2+ pathway
Binding of TCF/LEF:CTNNB1 to target gene promoters
Repression of WNT target genes
Repression of WNT target genes
Transcriptional Regulation by VENTX
RUNX3 regulates WNT signaling
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
Drugs
Etacrynic acid
Diseases
GWAS
Blood pressure measurement (high sodium intervention) (
24165912
)
Brain morphology (MOSTest) (
32665545
)
Cadmium levels (
26025379
)
Excessive hairiness (
29895819
)
ghrelin levels (
33852427
)
Gout (
22179738
)
Male-pattern baldness (
29146897
27182965
)
Monobrow (
27182965
)
Response to antidepressants in depression (
29998114
)
Thrombin-activatable fibrinolysis inhibitor activation peptide (
29378355
)
Airflow obstruction (
22837378
)
Blond vs. brown/black hair color (
30531825
)
Chronic lymphocytic leukemia (
28165464
26956414
23770605
)
Diastolic blood pressure (
27841878
)
Medication use (calcium channel blockers) (
31015401
)
Metabolic traits (
19060910
)
Multiple sclerosis (
31604244
)
Systemic lupus erythematosus (
22291604
)
Systolic blood pressure (
27841878
30578418
)
Tooth agenesis (mandibular second premolars) (
29364747
)
Interacting Genes
15 interacting genes:
ALX1
AMBRA1
CEBPE
EMX1
FOXA3
GATA4
HOXA3
HOXB13
HOXB6
HOXD3
IQUB
LEF1
PARVG
SOX10
SOX2
35 interacting genes:
ALX4
ALYREF
AURKA
BAX
BUB1
CDX1
CTNNB1
DPYSL2
EP300
KPNA1
KPNA2
MITF
MLH1
MLH3
MSH2
NFE2L2
NLK
NOTCH1
NRAS
PIAS4
PITX2
RAP1GDS1
RB1
RUNX2
SMAD1
SMAD2
SMAD3
SMAD4
STK11
SUMO2
TLE1
TLE2
TRA
UBTF
ZBTB3
Entrez ID
60529
51176
HPRD ID
05661
01075
Ensembl ID
ENSG00000052850
ENSG00000138795
Uniprot IDs
Q9H161
Q659G9
Q9UJU2
PDB IDs
2M0C
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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