ALX4 and HOXD3

Number of citations of the paper that reports this interaction (PubMedID 20211142)
361

Data Source:
BioGRID (two hybrid)

		ALX4	HOXD3
Description		ALX homeobox 4	homeobox D3
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Aggresome Nuclear Body
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Skeletal System Development Hair Follicle Development Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Post-embryonic Development Anterior/posterior Pattern Specification Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Embryonic Skeletal System Morphogenesis Roof Of Mouth Development	Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Cell-matrix Adhesion Notch Signaling Pathway Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Thyroid Gland Development Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Cartilage Development
Pathways			Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Blood pressure measurement (high sodium intervention) ( 24165912) Brain morphology (MOSTest) ( 32665545) Cadmium levels ( 26025379) Excessive hairiness ( 29895819) ghrelin levels ( 33852427) Gout ( 22179738) Male-pattern baldness ( 29146897 27182965) Monobrow ( 27182965) Response to antidepressants in depression ( 29998114) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)	Estimated glomerular filtration rate ( 31015462) Male-pattern baldness ( 29146897 28196072) Mucinous ovarian carcinoma ( 26075790) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Ovarian cancer ( 20852632) Pelvic organ prolapse (moderate/severe) ( 26545240)
Interacting Genes		15 interacting genes: ALX1 AMBRA1 CEBPE EMX1 FOXA3 GATA4 HOXA3 HOXB13 HOXB6 HOXD3 IQUB LEF1 PARVG SOX10 SOX2	7 interacting genes: ALX4 DDB1 HMGB1 HOXC8 IGFN1 NFKBID SMARCD1
Entrez ID		60529	3232
HPRD ID		05661	00863
Ensembl ID		ENSG00000052850	ENSG00000128652
Uniprot IDs		Q9H161	P31249
PDB IDs		2M0C
Enriched GO Terms of Interacting Partners?
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