LEF1 and MITF

Number of citations of the paper that reports this interaction (PubMedID 12032083)
57

Data Source:
BioGRID (affinity chromatography technology, pull down, pull down, two hybrid)
HPRD (two hybrid, in vivo, in vitro)

		LEF1	MITF
Description		lymphoid enhancer binding factor 1	melanocyte inducing transcription factor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Protein-DNA Complex Beta-catenin-TCF Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Protein-containing Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding DNA Binding, Bending Estrogen Receptor Binding Histone Binding Histone Deacetylase Binding Sequence-specific DNA Binding Gamma-catenin Binding Armadillo Repeat Domain Binding C2H2 Zinc Finger Domain Binding Transcription Regulator Inhibitor Activity Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Protein Dimerization Activity E-box Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Branching Involved In Blood Vessel Morphogenesis Osteoblast Differentiation Somitogenesis Epithelial To Mesenchymal Transition Sprouting Angiogenesis Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Dentate Gyrus Development Forebrain Radial Glial Cell Differentiation Forebrain Neuroblast Division Formation Of Radial Glial Scaffolds Positive Regulation Of Wnt Signaling Pathway Neutrophil Differentiation Embryonic Limb Morphogenesis Positive Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of Granulocyte Differentiation Mammary Gland Development Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-4 Production Negative Regulation Of Interleukin-5 Production T Cell Receptor V(D)J Recombination B Cell Proliferation Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Tongue Development Positive Regulation By Host Of Viral Transcription Histone H3 Acetylation Histone H4 Acetylation T-helper 1 Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Formation Sensory Perception Of Taste Anatomical Structure Regression Canonical Wnt Signaling Pathway Face Morphogenesis Cell Chemotaxis Chorio-allantoic Fusion Trachea Gland Development Secondary Palate Development Cellular Response To Cytokine Stimulus Cellular Response To Interleukin-4 Positive Regulation Of Cell Proliferation In Bone Marrow Negative Regulation Of Apoptotic Process In Bone Marrow Cell Histone H3-K56 Acetylation Apoptotic Process Involved In Blood Vessel Morphogenesis Positive Regulation Of Chondrocyte Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Osteoclast Differentiation Melanocyte Differentiation Negative Regulation Of Cell Migration Regulation Of Cell Population Proliferation Camera-type Eye Development Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Cell Fate Commitment Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Bone Remodeling Protein-containing Complex Assembly Positive Regulation Of DNA-templated Transcription, Initiation Regulation Of RNA Biosynthetic Process
Pathways		Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Ca2+ pathway Binding of TCF/LEF:CTNNB1 to target gene promoters Repression of WNT target genes Repression of WNT target genes Transcriptional Regulation by VENTX RUNX3 regulates WNT signaling Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis	SUMOylation of transcription factors
Drugs		Etacrynic acid
Diseases
GWAS		Airflow obstruction ( 22837378) Blond vs. brown/black hair color ( 30531825) Chronic lymphocytic leukemia ( 28165464 26956414 23770605) Diastolic blood pressure ( 27841878) Medication use (calcium channel blockers) ( 31015401) Metabolic traits ( 19060910) Multiple sclerosis ( 31604244) Systemic lupus erythematosus ( 22291604) Systolic blood pressure ( 27841878 30578418) Tooth agenesis (mandibular second premolars) ( 29364747)	Apolipoprotein B levels ( 32203549) Blond vs. brown/black hair color ( 30531825) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Carotid intima media thickness x smoking interaction ( 32117412) Chronotype ( 30696823) Circulating fibroblast growth factor 23 levels ( 30217807) Coronary artery disease ( 33020668) Cortical surface area (MOSTest) ( 32665545) Cutaneous malignant melanoma ( 32341527) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Myocardial infarction ( 33532862) Neutrophil count ( 32888494) Nevus count or cutaneous melanoma ( 32341527) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 27841878) QRS complex (12-leadsum) ( 27659466) Red blood cell count ( 32888494 27863252) Renal underexcretion gout ( 32238385) Severe influenza A (H1N1) infection ( 26379185) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549) Waist-hip index ( 34021172)
Interacting Genes		35 interacting genes: ALX4 ALYREF AURKA BAX BUB1 CDX1 CTNNB1 DPYSL2 EP300 KPNA1 KPNA2 MITF MLH1 MLH3 MSH2 NFE2L2 NLK NOTCH1 NRAS PIAS4 PITX2 RAP1GDS1 RB1 RUNX2 SMAD1 SMAD2 SMAD3 SMAD4 STK11 SUMO2 TLE1 TLE2 TRA UBTF ZBTB3	32 interacting genes: ADRB2 APP CTNNB1 EBP EP300 FBXO7 FOS GSK3B HINT1 HK3 LEF1 MAPK1 MAPK14 MARK3 OTX2 PATZ1 PAX3 PAX6 PDGFRB PIAS1 PIAS2 PIAS3 PSMD14 RERE RPS6KA1 SPI1 STUB1 SUMO1 TFE3 TFEB TFEC UBE2I
Entrez ID		51176	4286
HPRD ID		01075	01138
Ensembl ID		ENSG00000138795	ENSG00000187098
Uniprot IDs		Q659G9 Q9UJU2	A0A087WXU1 B4DNC7 O75030 Q8WYR3
PDB IDs			4C7N
Enriched GO Terms of Interacting Partners?
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