RNF5 and SLC1A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		RNF5	SLC1A1
Description		ring finger protein 5	solute carrier family 1 member 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondrial Membrane Endoplasmic Reticulum Quality Control Compartment	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Apical Plasma Membrane Axon Dendrite Early Endosome Membrane Late Endosome Membrane Asymmetric Synapse Neuronal Cell Body Synaptic Cleft Dendritic Spine Dendritic Shaft Perikaryon Axon Terminus Membrane Raft Recycling Endosome Membrane Extracellular Exosome Cell Periphery Glial Cell Projection Apical Dendrite Presynapse Perisynaptic Space Distal Dendrite Proximal Dendrite
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Identical Protein Binding Ubiquitin-like Protein Conjugating Enzyme Binding Protein-containing Complex Binding Ubiquitin Protein Ligase Activity	Anion Channel Activity L-glutamate Transmembrane Transporter Activity High-affinity Glutamate Transmembrane Transporter Activity Protein Binding Chloride Transmembrane Transporter Activity L-aspartate Transmembrane Transporter Activity Glutamate:sodium Symporter Activity Glutamate Binding Cysteine Transmembrane Transporter Activity Identical Protein Binding Metal Ion Binding D-aspartate Transmembrane Transporter Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Response To Bacterium Negative Regulation Of Autophagy Ubiquitin-dependent ERAD Pathway Protein Destabilization ERAD Pathway Cellular Protein Catabolic Process Transmembrane Transport Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination ER-associated Misfolded Protein Catabolic Process Endoplasmic Reticulum Mannose Trimming Regulation Of Autophagosome Assembly	Behavioral Fear Response Response To Amphetamine Glutathione Biosynthetic Process Superoxide Metabolic Process Ion Transport Neurotransmitter Transport Cellular Zinc Ion Homeostasis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Dopamine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Brain Development Memory Grooming Behavior Locomotory Behavior Positive Regulation Of Heart Rate Gene Expression Retina Layer Formation L-glutamate Transmembrane Transport Peptidyl-serine Phosphorylation Cytokine-mediated Signaling Pathway Neurogenesis Adult Behavior Activation Of Protein Kinase B Activity Maintenance Of Blood-brain Barrier Response To Decreased Oxygen Levels Neuron Death In Response To Oxidative Stress Dopamine Metabolic Process Cysteine Transport Response To Morphine Negative Regulation Of Neuron Apoptotic Process Blood Vessel Morphogenesis Response To Axon Injury Synapse Organization L-glutamate Import Righting Reflex Heart Contraction Long-term Synaptic Potentiation Motor Behavior Transepithelial Transport D-aspartate Transport L-aspartate Transmembrane Transport D-aspartate Import Across Plasma Membrane Cellular Response To Ammonium Ion Cellular Response To Mercury Ion Cellular Response To Cocaine Cellular Response To Organic Cyclic Compound Zinc Ion Transmembrane Transport Response To Anesthetic Regulation Of Protein Targeting To Membrane Glutamate Homeostasis Motor Neuron Apoptotic Process L-glutamate Import Across Plasma Membrane Neurotransmitter Receptor Transport To Plasma Membrane L-aspartate Import Across Plasma Membrane Transport Across Blood-brain Barrier Chloride Transmembrane Transport Cysteine Transmembrane Transport Conditioned Place Preference
Pathways		ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC)	Glutamate Neurotransmitter Release Cycle Transport of inorganic cations/anions and amino acids/oligopeptides Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)
Drugs			Aspartic acid Glutamic acid
Diseases
GWAS		Advanced glycation end-product levels ( 26083729) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Idiopathic membranous nephropathy ( 21323541) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Prostate cancer ( 23535732) Ulcerative colitis ( 28067908) Waist circumference ( 31453325) Waist circumference variance ( 31453325)	Coronary artery calcification ( 23870195) Metabolite levels ( 23823483) Pancreatic cancer ( 22158540) Response to antipsychotic treatment in schizophrenia ( 29503163) Response to risperidone in schizophrenia ( 29503163) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		50 interacting genes: ABHD16A ARL6IP1 CFTR CYB561 CYB561A3 DGAT2L6 FAM241B FHOD1 GLP1R INSIG2 JKAMP LEPROTL1 MAVS MPDZ MS4A1 ORMDL3 PLP2 PLPP6 PRAF2 PXN RABAC1 RHBDD1 RUSF1 SCD SEC22A SLC1A1 SLC38A7 TGFBR1 TMEM120B TMEM242 TNFAIP3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2K UBE2N UBE2U UBE2V1 UBE2W UBE2Z UBTD1 YIPF1 YIPF2 YIPF4	16 interacting genes: APP ARL6IP5 C1GALT1 ERGIC3 EWSR1 FAM209A FCER1G FXYD3 LDLRAD1 LMNA PAGE1 PRKCA RNF5 SLC35A1 SYNPR TMEM179B
Entrez ID		6048	6505
HPRD ID		04057	00597
Ensembl ID		ENSG00000204308	ENSG00000106688
Uniprot IDs		A0A024RCQ4 Q99942	P43005
PDB IDs			6S3Q
Enriched GO Terms of Interacting Partners?
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