SLC1A1 and ARL6IP5

Number of citations of the paper that reports this interaction (PubMedID 11242046)
48

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		SLC1A1	ARL6IP5
Description		solute carrier family 1 member 1	ADP ribosylation factor like GTPase 6 interacting protein 5
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Apical Plasma Membrane Axon Dendrite Early Endosome Membrane Late Endosome Membrane Asymmetric Synapse Neuronal Cell Body Synaptic Cleft Dendritic Spine Dendritic Shaft Perikaryon Axon Terminus Membrane Raft Recycling Endosome Membrane Extracellular Exosome Cell Periphery Glial Cell Projection Apical Dendrite Presynapse Perisynaptic Space Distal Dendrite Proximal Dendrite	Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Anion Channel Activity L-glutamate Transmembrane Transporter Activity High-affinity Glutamate Transmembrane Transporter Activity Protein Binding Chloride Transmembrane Transporter Activity L-aspartate Transmembrane Transporter Activity Glutamate:sodium Symporter Activity Glutamate Binding Cysteine Transmembrane Transporter Activity Identical Protein Binding Metal Ion Binding D-aspartate Transmembrane Transporter Activity	Molecular_function Protein Binding
	Biological Process	Behavioral Fear Response Response To Amphetamine Glutathione Biosynthetic Process Superoxide Metabolic Process Ion Transport Neurotransmitter Transport Cellular Zinc Ion Homeostasis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Dopamine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Brain Development Memory Grooming Behavior Locomotory Behavior Positive Regulation Of Heart Rate Gene Expression Retina Layer Formation L-glutamate Transmembrane Transport Peptidyl-serine Phosphorylation Cytokine-mediated Signaling Pathway Neurogenesis Adult Behavior Activation Of Protein Kinase B Activity Maintenance Of Blood-brain Barrier Response To Decreased Oxygen Levels Neuron Death In Response To Oxidative Stress Dopamine Metabolic Process Cysteine Transport Response To Morphine Negative Regulation Of Neuron Apoptotic Process Blood Vessel Morphogenesis Response To Axon Injury Synapse Organization L-glutamate Import Righting Reflex Heart Contraction Long-term Synaptic Potentiation Motor Behavior Transepithelial Transport D-aspartate Transport L-aspartate Transmembrane Transport D-aspartate Import Across Plasma Membrane Cellular Response To Ammonium Ion Cellular Response To Mercury Ion Cellular Response To Cocaine Cellular Response To Organic Cyclic Compound Zinc Ion Transmembrane Transport Response To Anesthetic Regulation Of Protein Targeting To Membrane Glutamate Homeostasis Motor Neuron Apoptotic Process L-glutamate Import Across Plasma Membrane Neurotransmitter Receptor Transport To Plasma Membrane L-aspartate Import Across Plasma Membrane Transport Across Blood-brain Barrier Chloride Transmembrane Transport Cysteine Transmembrane Transport Conditioned Place Preference	Negative Regulation Of L-glutamate Import Across Plasma Membrane Glutathione Metabolic Process Learning Or Memory Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Negative Regulation Of Mitochondrial Membrane Potential Protein Transport L-glutamate Transmembrane Transport Positive Regulation Of Stress-activated MAPK Cascade Neuron Death In Response To Oxidative Stress Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Transport Cellular Response To Organic Cyclic Compound Protein Localization To Plasma Membrane L-glutamate Import Across Plasma Membrane
Pathways		Glutamate Neurotransmitter Release Cycle Transport of inorganic cations/anions and amino acids/oligopeptides Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)	Glutamate Neurotransmitter Release Cycle
Drugs		Aspartic acid Glutamic acid
Diseases
GWAS		Coronary artery calcification ( 23870195) Metabolite levels ( 23823483) Pancreatic cancer ( 22158540) Response to antipsychotic treatment in schizophrenia ( 29503163) Response to risperidone in schizophrenia ( 29503163) Squamous cell lung carcinoma ( 28604730)	Urate levels ( 31578528)
Interacting Genes		16 interacting genes: APP ARL6IP5 C1GALT1 ERGIC3 EWSR1 FAM209A FCER1G FXYD3 LDLRAD1 LMNA PAGE1 PRKCA RNF5 SLC35A1 SYNPR TMEM179B	10 interacting genes: ARL6 CCR2 CCR5 CLN8 KRAS MYCBP2 NOTCH1 PRAF2 SLC1A1 VKORC1
Entrez ID		6505	10550
HPRD ID		00597	09303
Ensembl ID		ENSG00000106688	ENSG00000144746
Uniprot IDs		P43005	A0A024R371 O75915
PDB IDs		6S3Q
Enriched GO Terms of Interacting Partners?
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