RAP2B and RAPGEF1

Number of citations of the paper that reports this interaction (PubMedID 9266971)
28

Data Source:
BioGRID (pull down)

		RAP2B	RAPGEF1
Description		RAP2B, member of RAS oncogene family	Rap guanine nucleotide exchange factor 1
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Bicellular Tight Junction Membrane Specific Granule Membrane Cell-cell Contact Zone Membrane Raft Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Membrane	Cytoplasm Early Endosome Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding
	Biological Process	Signal Transduction Microvillus Assembly Platelet Activation Negative Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Regulation Of Protein Tyrosine Kinase Activity Platelet Aggregation Establishment Of Endothelial Intestinal Barrier	Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Positive Regulation Of Neuron Projection Development Rap Protein Signal Transduction Nerve Growth Factor Signaling Pathway Positive Regulation Of GTPase Activity Establishment Of Endothelial Barrier Cellular Response To CAMP Regulation Of Cell Junction Assembly Cellular Response To Nerve Growth Factor Stimulus
Pathways		Neutrophil degranulation	Frs2-mediated activation Frs2-mediated activation Downstream signal transduction MET activates RAP1 and RAC1 RAC3 GTPase cycle Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL
Drugs
Diseases
GWAS		Cerebral amyloid deposition (PET imaging) ( 30361487) Chronotype ( 30696823) Cutaneous melanoma or hair colour ( 32341527) Metabolite levels ( 23823483) PR interval ( 32439900) Serum sulfate level ( 27412988)	Cerebrospinal fluid Î±-synuclein levels ( 29959729) Cutaneous malignant melanoma ( 32341527) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Kidney volume ( 34128465) Nevus count or cutaneous melanoma ( 32341527) Optic disc size ( 31809533)
Interacting Genes		10 interacting genes: CAMK2B PDE6D PRKAR2B RALGDS RAP1GDS1 RAPGEF1 RAPGEF2 RAPGEF5 RASSF5 RUNDC3A	20 interacting genes: ABL1 ATXN1 BCAR1 CRK CRKL EGFR GRB2 HCK HRAS MBIP NEDD9 PDGFRA RAP1A RAP1B RAP2B RHOQ RPS15 RRAS2 SHC1 SLC20A1
Entrez ID		5912	2889
HPRD ID		01548	02627
Ensembl ID		ENSG00000181467	ENSG00000107263
Uniprot IDs		P61225	Q13905
PDB IDs		1N4P 1N4Q 1N4R	5L23
Enriched GO Terms of Interacting Partners?
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