RAPGEF1 and MBIP

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		RAPGEF1	MBIP
Description		Rap guanine nucleotide exchange factor 1	MAP3K12 binding inhibitory protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Early Endosome Cytosol Intracellular Membrane-bounded Organelle	Nucleoplasm Nucleolus Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding	Protein Kinase Inhibitor Activity Protein Binding Identical Protein Binding
	Biological Process	Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Positive Regulation Of Neuron Projection Development Rap Protein Signal Transduction Nerve Growth Factor Signaling Pathway Positive Regulation Of GTPase Activity Establishment Of Endothelial Barrier Cellular Response To CAMP Regulation Of Cell Junction Assembly Cellular Response To Nerve Growth Factor Stimulus	Positive Regulation Of Gene Expression Negative Regulation Of Catalytic Activity Histone H3 Acetylation Positive Regulation Of JNK Cascade
Pathways		Frs2-mediated activation Frs2-mediated activation Downstream signal transduction MET activates RAP1 and RAC1 RAC3 GTPase cycle Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL	HATs acetylate histones
Drugs
Diseases
GWAS		Cerebrospinal fluid Î±-synuclein levels ( 29959729) Cutaneous malignant melanoma ( 32341527) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Kidney volume ( 34128465) Nevus count or cutaneous melanoma ( 32341527) Optic disc size ( 31809533)	Hypertension ( 31513605) Thyroid cancer ( 22267200) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997 25743335)
Interacting Genes		20 interacting genes: ABL1 ATXN1 BCAR1 CRK CRKL EGFR GRB2 HCK HRAS MBIP NEDD9 PDGFRA RAP1A RAP1B RAP2B RHOQ RPS15 RRAS2 SHC1 SLC20A1	47 interacting genes: BFSP2 CALM1 CCDC85B CCNC CEP63 COPS4 DGCR6 DGCR6L DIP2A DRC7 EPB41L3 EXOC8 FXR1 FXR2 ING5 KAT14 KLC3 LIMS1 LMNB1 LMO2 LMO3 MAP3K12 MAPK6 MCM7 MIS18A MOAP1 MYD88 NDEL1 NINL PIK3R3 PLEKHF2 POLR1C PPFIA1 RAP1GDS1 RAPGEF1 SHANK3 SMARCB1 STX11 TGIF2LY TRIM55 TRIM63 TSC1 TXLNA TXLNB VPS28 VTA1 WDR5
Entrez ID		2889	51562
HPRD ID		02627	14368
Ensembl ID		ENSG00000107263	ENSG00000151332
Uniprot IDs		Q13905	B2RCV0 Q9NS73
PDB IDs		5L23
Enriched GO Terms of Interacting Partners?
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