ARHGAP22 and DEF6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ARHGAP22	DEF6
Description		Rho GTPase activating protein 22	DEF6 guanine nucleotide exchange factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Focal Adhesion Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Filopodium Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activator Activity Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Angiogenesis Signal Transduction Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity Regulation Of Postsynapse Organization	Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle	RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle
Drugs
Diseases
GWAS		Conduct disorder ( 20585324) Daytime sleep phenotypes ( 27126917) Diabetic retinopathy ( 21310492) Macular thickness ( 30535121) Refractive error ( 32231278) Self-employment ( 23593239) Systolic blood pressure ( 31134134) Systolic blood pressure (education interaction) ( 31134134)	Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Height ( 18391951 33713608) Hip circumference adjusted for BMI ( 34021172) Lymphocyte counts ( 32888494) Neutrophil count ( 32888494) Systemic lupus erythematosus ( 33493351 28714469) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)
Interacting Genes		13 interacting genes: ALG11 CACNA1A CCNDBP1 CDC42 DEF6 FXR1 GPRIN2 IL1RAPL1 MAPK8 PTPN20 RAC1 RHOA ZNF488	32 interacting genes: APP ARHGAP22 BEGAIN CCDC88B CDC42 CDC42EP1 EIF4ENIF1 GOLGA6A GOLGA6L9 HOMEZ INCA1 INTS2 KIAA1328 KRT31 L3MBTL3 LCK PBXIP1 PLSCR1 PSMA1 PTK2 RAC1 RAC2 RAPGEF4 RASAL3 REL RHOA SAP18 SLU7 TCF4 TEPSIN ZAP70 ZNF688
Entrez ID		58504	50619
HPRD ID		12476	10869
Ensembl ID		ENSG00000128805	ENSG00000023892
Uniprot IDs		A0A2X0SFC0 Q7Z5H3	Q9H4E7
PDB IDs
Enriched GO Terms of Interacting Partners?
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