RPRM and CD33

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		RPRM	CD33
Description		reprimo, TP53 dependent G2 arrest mediator homolog	CD33 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Integral Component Of Membrane	Nucleoplasm Peroxisome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Specific Granule Membrane Tertiary Granule Membrane
	Molecular Function	Protein Binding	Protein Binding Protein Phosphatase Binding Carbohydrate Binding Sialic Acid Binding Signaling Receptor Activity
	Biological Process	Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle	Immune Response-inhibiting Signal Transduction Cell Adhesion Signal Transduction Cell-cell Signaling Negative Regulation Of Cell Population Proliferation Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Protein Secretion Negative Regulation Of Calcium Ion Transport Cell-cell Adhesion Negative Regulation Of Monocyte Activation Positive Regulation Of Protein Tyrosine Phosphatase Activity
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation
Drugs			Gemtuzumab ozogamicin AVE9633
Diseases
GWAS		Anti-saccade response ( 29064472) Blood trace element (Zn levels) ( 23720494) Heel bone mineral density ( 30598549) Lung cancer ( 28604730) Recurrent major depressive disorder x sex interaction ( 34099189)	Alzheimer's disease ( 18976728 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 24162737 28714976) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Basophil count ( 32888494) Blood protein levels ( 30072576 29875488 28240269) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Eosinophil counts ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) HIV-1 susceptibility ( 25786224) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Triacylglyceride levels ( 31551469) White blood cell count ( 32888494 27863252)
Interacting Genes		79 interacting genes: ADGRG3 AMIGO1 AQP6 ARFIP1 ASGR2 BNIP3 BSCL2 BTNL9 C16orf54 CD33 CD53 CD69 CLDN5 CLDN7 CLDN9 CLEC17A CLEC2D COQ8A CREB3 CXorf66 EHHADH EMP1 FAM209A FAM210B FATE1 FBXL19 FCGR1A FFAR2 FGD2 FKBP7 FNDC9 GAD2 GJA5 GJB3 GJB5 GNG13 GPR37L1 GPR42 HHLA2 HIP1 HSD17B13 KCNJ6 LAPTM5 LHFPL5 LMNA LPAR6 MPP1 MS4A4A MTIF3 OPRD1 OPRM1 PBX3 PDZK1IP1 PLEKHF2 PNKP SCAND1 SDCBP SENP2 SLC18A1 SLC38A1 SMIM3 SNX11 SNX12 SNX3 SPACA1 SPCS1 STOM SUSD3 SYT16 TM4SF18 TMEM106C TMEM237 TMEM79 TMEM80 TMEM86B TSPO2 TTPA WDFY2 ZDHHC22	22 interacting genes: BBS9 BMP10 C3orf52 CXCL9 CYB5B EMD GIMAP5 HERC3 KRT31 KRT35 KRT40 PTPN11 PTPN6 RPRM SCD SRC THSD7A TMBIM1 TMEM100 TMEM243 TNMD UBIAD1
Entrez ID		56475	945
HPRD ID		18002	01165
Ensembl ID		ENSG00000177519	ENSG00000105383
Uniprot IDs		Q9NS64	P20138 Q546G0
PDB IDs			5IHB 5J06 5J0B 6D48 6D49 6D4A 6TL8 7AW6
Enriched GO Terms of Interacting Partners?
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