PACS1 and VAMP4

Number of citations of the paper that reports this interaction (PubMedID 14608369)
28

Data Source:
HPRD (in vivo, in vitro)

		PACS1	VAMP4
Description		phosphofurin acidic cluster sorting protein 1	vesicle associated membrane protein 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol COPI-coated Vesicle	Golgi Membrane Lysosome Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Synaptic Vesicle Cell Surface Transport Vesicle Integral Component Of Synaptic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane SNARE Complex Trans-Golgi Network Membrane
	Molecular Function	Protein Binding Transmembrane Transporter Binding	Protein Binding
	Biological Process	Protein Localization To Golgi Apparatus Protein Localization To Plasma Membrane	Microtubule Cytoskeleton Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Synaptic Vesicle To Endosome Fusion SNARE Complex Assembly Golgi To Plasma Membrane Protein Transport Golgi Ribbon Formation Regulation Of Synaptic Vesicle Endocytosis
Pathways		Nef mediated downregulation of MHC class I complex cell surface expression	Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Bipolar disorder ( 21926972 33263727 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Electroencephalogram traits ( 25387704) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494) Obesity (early onset extreme) ( 23563609) Serum uric acid levels ( 32514006) Waist circumference adjusted for body mass index ( 34021172)	Cognitive decline rate in late mild cognitive impairment ( 26252872) Hippocampal atrophy ( 25625606) Metabolite levels ( 23823483) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		20 interacting genes: AOPEP CABP4 CARNS1 CLCN7 CSNK2A1 FURIN GDI1 GGA3 IGF2R JUN KLC2 LAMA4 MCAM OTUB1 PKD2 PPP2CA PPP2CB SLC24A1 USP9Y VAMP4	46 interacting genes: ANKS6 AP1M1 AQP6 ARL13B BCL2L13 CISD2 CPLX4 CSNK2A1 CYB5R3 CYP1A1 DNAJC5 EBP ELOVL4 ERGIC3 EVI2B FAM209A FAM210B GPR152 GPX8 KASH5 LDLRAD1 LEUTX MFF MGST3 MTIF3 PACS1 PSCA PTGES REEP4 RETREG3 SAR1A SEC11C SLC10A6 SNAP29 SSMEM1 STOM STX16 STX1A STX4 STX6 SYT2 TM4SF19 TMEM205 TMEM51 TMX2 TRIM54
Entrez ID		55690	8674
HPRD ID		06320	06070
Ensembl ID		ENSG00000175115	ENSG00000117533
Uniprot IDs		A0A024R5H6 Q6VY07	O75379 Q6IAZ3
PDB IDs
Enriched GO Terms of Interacting Partners?
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