PACS1 and OTUB1

		PACS1	OTUB1
Description		phosphofurin acidic cluster sorting protein 1	OTU deubiquitinase, ubiquitin aldehyde binding 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol COPI-coated Vesicle	Nucleus Nucleoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Transmembrane Transporter Binding	Thiol-dependent Deubiquitinase Protein Binding NEDD8-specific Protease Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding
	Biological Process	Protein Localization To Golgi Apparatus Protein Localization To Plasma Membrane	Adaptive Immune Response DNA Repair Cellular Response To DNA Damage Stimulus Protein K48-linked Deubiquitination Cellular Response To Interleukin-1 Negative Regulation Of Histone H2A K63-linked Ubiquitination Negative Regulation Of Double-strand Break Repair
Pathways		Nef mediated downregulation of MHC class I complex cell surface expression	Ub-specific processing proteases Ovarian tumor domain proteases
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Bipolar disorder ( 21926972 33263727 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Electroencephalogram traits ( 25387704) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494) Obesity (early onset extreme) ( 23563609) Serum uric acid levels ( 32514006) Waist circumference adjusted for body mass index ( 34021172)	Bipolar disorder ( 31043756)
Interacting Genes		20 interacting genes: AOPEP CABP4 CARNS1 CLCN7 CSNK2A1 FURIN GDI1 GGA3 IGF2R JUN KLC2 LAMA4 MCAM OTUB1 PKD2 PPP2CA PPP2CB SLC24A1 USP9Y VAMP4	58 interacting genes: ACVR1 ACVR1B ANXA1 ANXA7 AURKA BIRC2 BMPR1A BMPR1B CD274 CDKN1A CPEB2 CSNK2A1 ECT2 ESR1 FOXM1 H2AX IL1RL2 KDM1A MAPT NEDD8 PACS1 PJA1 RFFL RHOA RNF126 RNF128 SLC7A11 SMAD2 SMAD3 SMAD4 SMAD9 SNAI1 TGFBR1 TP53 TRAF6 TRIM54 TRIM55 TRIM63 TSC22D1 TTR UBA6 UBC UBD UBE2D1 UBE2D2 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2N UBE2S UBE2V2 UBE2Z UBE4B USP15 USP21 USP28
Entrez ID		55690	55611
HPRD ID		06320	08493
Ensembl ID		ENSG00000175115	ENSG00000167770
Uniprot IDs		A0A024R5H6 Q6VY07	B3KUV5 Q96FW1
PDB IDs			2ZFY 3VON 4DDG 4DDI 4DHZ 4I6L 4LDT
Enriched GO Terms of Interacting Partners?
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