UBE2W and RNF2

Number of citations of the paper that reports this interaction (PubMedID 19549727)
74

Data Source:
BioGRID (two hybrid)

		UBE2W	RNF2
Description		ubiquitin conjugating enzyme E2 W	ring finger protein 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Ubiquitin Ligase Complex Euchromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex MLL1 Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity RING-like Zinc Finger Domain Binding
	Biological Process	Protein Polyubiquitination DNA Repair Protein Monoubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Response To Misfolded Protein	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Gastrulation With Mouth Forming Second Germ Cell Development Anterior/posterior Axis Specification Gene Expression Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination Negative Regulation Of DNA-binding Transcription Factor Activity
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Cervical high-risk human papilloma virus infection ( 33225922) Malaria ( 31844061) Manganese levels ( 26025379) Urate levels in obese individuals ( 25811787)	Clopidogrel active metabolite levels ( 28207573) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Obesity-related traits ( 23251661)
Interacting Genes		80 interacting genes: AKR1C3 AMFR ATXN3 BARD1 BFAR BIRC2 BIRC8 BRCA1 CADPS2 CBL CHFR CNOT4 DNMT3B DTX3 DTX3L DZIP3 EED ELOC FANCL LRSAM1 MAP3K1 MAPT MARCHF3 MARCHF5 MGRN1 MIB1 MID1 MKRN1 MKRN3 MUL1 PJA2 POLR2C PSTPIP1 RFWD3 RMND5B RNF10 RNF103 RNF111 RNF114 RNF115 RNF123 RNF125 RNF138 RNF14 RNF150 RNF152 RNF165 RNF166 RNF167 RNF183 RNF185 RNF2 RNF26 RNF31 RNF4 RNF5 RNF8 ROPN1 SNCA STUB1 TOPORS TRIM17 TRIM2 TRIM23 TRIM27 TRIM31 TRIM35 TRIM39 TRIM5 TRIM59 TRIM8 UBA1 UBOX5 UFM1 UHRF2 USHBP1 XIAP ZNRF1 ZNRF2 ZNRF4	55 interacting genes: ABCB1 AMBRA1 AUTS2 BAALC BMI1 CASP3 CASP9 CBX4 DYSF ERG H2AC18 H2AC20 H2AC4 H3-4 KAT8 KMT2A MBD1 MTNR1A OTUD6A PCGF2 PCGF6 PGP PHB2 PHC1 PHC2 PLK1 PSMC4 RING1 RRM1 RYBP SIK1 SMURF2 SSX2 TARDBP TFCP2 TSC22D2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2J1 UBE2K UBE2L3 UBE2U UBE2V1 UBE2V2 UBE2W USP11 USP19 WASHC1
Entrez ID		55284	6045
HPRD ID		07724	07028
Ensembl ID		ENSG00000104343	ENSG00000121481
Uniprot IDs		Q96B02 Q96FI0 X6REH9	Q99496
PDB IDs		2A7L 2MT6	2H0D 3GS2 3H8H 3IXS 3RPG 4R8P 4S3O
Enriched GO Terms of Interacting Partners?
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