RNF2 and AUTS2

Number of citations of the paper that reports this interaction (PubMedID 25519132)
103

Data Source:
BioGRID (biochemical, pull down, affinity chromatography technology)

		RNF2	AUTS2
Description		ring finger protein 2	activator of transcription and developmental regulator AUTS2
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Euchromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex MLL1 Complex	Cellular_component Nucleus Cytoplasm Actin Cytoskeleton Growth Cone
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity RING-like Zinc Finger Domain Binding	Chromatin Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Gastrulation With Mouth Forming Second Germ Cell Development Anterior/posterior Axis Specification Gene Expression Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination Negative Regulation Of DNA-binding Transcription Factor Activity	Neuron Migration Positive Regulation Of Lamellipodium Assembly Actin Cytoskeleton Reorganization Positive Regulation Of Rac Protein Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Axon Extension Positive Regulation Of Histone H3-K4 Methylation Dendrite Extension Positive Regulation Of Histone H4-K16 Acetylation
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases
GWAS		Clopidogrel active metabolite levels ( 28207573) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Obesity-related traits ( 23251661)	Adult body size ( 32376654) Adventurousness ( 30643258) Alcohol consumption ( 21471458 31358974) Alcohol consumption (drinks per week) ( 30679032) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Bipolar disorder ( 22925353) Body mass index ( 28892062 25673413) Cerebrospinal fluid p-tau levels in normal cognition ( 29274321) Childhood ear infection ( 27182965 28928442) Chronotype ( 30696823) Coffee consumption ( 31046077) Cognitive decline (age-related) ( 28078323) Declining hemoglobin trajectory in blood donors ( 33491795) Diastolic blood pressure ( 30224653) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) Hearing loss in noise exposure ( 33242228) Immune reponse to smallpox (secreted IL-2) ( 22610502) Irritable mood ( 29500382) Lymphocyte counts ( 32888494) Male-pattern baldness ( 29146897 22693459 27182965 28196072) Mean corpuscular hemoglobin ( 32888494) Monobrow ( 27182965) Mosquito bite size ( 28199695) Motion sickness ( 25628336) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) QT interval ( 29213071) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to serotonin reuptake inhibitors in non-psychotic unipolar depression ( 26348319) Sleep duration ( 30531941) Smoking initiation ( 33082346) Type 2 diabetes ( 31118516 32499647 30718926) Urinary albumin-to-creatinine ratio ( 31630189 31511532) Walking pace ( 33128006)
Interacting Genes		55 interacting genes: ABCB1 AMBRA1 AUTS2 BAALC BMI1 CASP3 CASP9 CBX4 DYSF ERG H2AC18 H2AC20 H2AC4 H3-4 KAT8 KMT2A MBD1 MTNR1A OTUD6A PCGF2 PCGF6 PGP PHB2 PHC1 PHC2 PLK1 PSMC4 RING1 RRM1 RYBP SIK1 SMURF2 SSX2 TARDBP TFCP2 TSC22D2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2J1 UBE2K UBE2L3 UBE2U UBE2V1 UBE2V2 UBE2W USP11 USP19 WASHC1	4 interacting genes: CSNK2A1 EP300 KRTAP6-3 RNF2
Entrez ID		6045	26053
HPRD ID		07028	06276
Ensembl ID		ENSG00000121481	ENSG00000158321
Uniprot IDs		Q99496	Q8WXX7
PDB IDs		2H0D 3GS2 3H8H 3IXS 3RPG 4R8P 4S3O
Enriched GO Terms of Interacting Partners?
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