AUP1 and UBE2G2

Number of citations of the paper that reports this interaction (PubMedID 22119785)
230

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology)

		AUP1	UBE2G2
Description		AUP1 lipid droplet regulating VLDL assembly factor	ubiquitin conjugating enzyme E2 G2
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GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase ERAD-L Complex Autophagosome Endoplasmic Reticulum Lipid Droplet Membrane Integral Component Of Endoplasmic Reticulum Membrane Cytoplasmic Vesicle Extracellular Exosome	Endoplasmic Reticulum Lipid Droplet Cytosol
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding Ubiquitin-protein Transferase Activator Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Identical Protein Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Response To Virus Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Lipid Droplet Organization Regulation Of Catalytic Activity Lipophagy ER-associated Misfolded Protein Catabolic Process Lipid Droplet Formation Protein Localization To Lipid Droplet	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent ERAD Pathway Cellular Response To Interferon-beta Cellular Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol
Pathways			Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Alanine aminotransferase levels ( 33547301)
Interacting Genes		9 interacting genes: GPR35 ITGA1 ITGA2 ITGA2B ITGA5 ITGAM ITGAV RNF11 UBE2G2	41 interacting genes: AMFR ARL14 AUP1 BIRC8 CBL CNNM3 CPOX CUL9 ECPAS FARP2 HBS1L KDM2A MDM2 MGRN1 MLLT6 MUL1 NDUFS4 POLR3F PRKN PSMG1 RBX1 RC3H1 RC3H2 RFFL RNF111 RNF146 RNF157 RNF168 RNF26 RNF5 TMEM45B TRAPPC10 TRIM3 TRIM43 UBA1 UBA6 UBC UBE2J2 UBE3A VAMP8 ZNRF4
Entrez ID		550	7327
HPRD ID		03892	04387
Ensembl ID		ENSG00000115307	ENSG00000184787
Uniprot IDs		Q9Y679	P60604
PDB IDs		2EKF	2CYX 2KLY 2LXP 3H8K 4LAD
Enriched GO Terms of Interacting Partners?
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