UBE2G2 and NDUFS4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		UBE2G2	NDUFS4
Description		ubiquitin conjugating enzyme E2 G2	NADH:ubiquinone oxidoreductase subunit S4
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GO Annotations	Cellular Component	Endoplasmic Reticulum Lipid Droplet Cytosol	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Identical Protein Binding Ubiquitin Conjugating Enzyme Activity	Protein Binding NADH Dehydrogenase (ubiquinone) Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent ERAD Pathway Cellular Response To Interferon-beta Cellular Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol	Regulation Of Protein Phosphorylation Mitochondrial Electron Transport, NADH To Ubiquinone Brain Development Mitochondrial Respiratory Chain Complex I Assembly Cellular Respiration Positive Regulation Of Fibroblast Proliferation Response To CAMP Reactive Oxygen Species Metabolic Process
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Respiratory electron transport Complex I biogenesis
Drugs			NADH
Diseases
GWAS		Alanine aminotransferase levels ( 33547301)	Acne (severe) ( 24927181) Blond vs. brown/black hair color ( 30531825) Midgestational circulating levels of PCBs ( 28235828) Mitochondrial heteroplasmy measurement ( 33731350) Monobrow ( 27182965) Night sleep phenotypes ( 27126917) Schizophrenia ( 34099189) Schizophrenia x sex interaction ( 34099189) Verbal memory ( 29907492) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)
Interacting Genes		41 interacting genes: AMFR ARL14 AUP1 BIRC8 CBL CNNM3 CPOX CUL9 ECPAS FARP2 HBS1L KDM2A MDM2 MGRN1 MLLT6 MUL1 NDUFS4 POLR3F PRKN PSMG1 RBX1 RC3H1 RC3H2 RFFL RNF111 RNF146 RNF157 RNF168 RNF26 RNF5 TMEM45B TRAPPC10 TRIM3 TRIM43 UBA1 UBA6 UBC UBE2J2 UBE3A VAMP8 ZNRF4	2 interacting genes: APP UBE2G2
Entrez ID		7327	4724
HPRD ID		04387	04073
Ensembl ID		ENSG00000184787	ENSG00000164258
Uniprot IDs		P60604	A0A0S2Z433 O43181
PDB IDs		2CYX 2KLY 2LXP 3H8K 4LAD	5XTB 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?
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