DIRAS2 and RAP1GDS1

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		DIRAS2	RAP1GDS1
Description		DIRAS family GTPase 2	Rap1 GTPase-GDP dissociation stimulator 1
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GO Annotations	Cellular Component	Plasma Membrane	Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	GTPase Activator Activity Protein Binding
	Biological Process	Signal Transduction Positive Regulation Of MAP Kinase Activity	Vascular Associated Smooth Muscle Contraction Myosin Filament Assembly Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of GTPase Activity Positive Regulation Of Mitochondrial Calcium Ion Concentration
Pathways			RHOT2 GTPase cycle RHOT1 GTPase cycle
Drugs
Diseases
GWAS		Cognitive test performance ( 17903297) Logical memory (immediate recall) in Alzheimer's disease dementia ( 29274321) Multiple sclerosis ( 31604244) Protein quantitative trait loci ( 18464913)	Biochemical measures ( 19260141) Response to fenofibrate (total cholesterol levels) ( 27002377) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)
Interacting Genes		3 interacting genes: RAP1GDS1 RIPPLY1 UNC45A	28 interacting genes: ABCB7 ANTXR2 CDC42 DIRAS1 DIRAS2 DOC2A EGFR HRAS KIFAP3 KRAS LEF1 MBIP MED28 NRAS OGT PLEKHB1 PTPRF PUF60 RAB6B RAC1 RAP1A RAP2B RAP2C RHOA RNF19B RRAS RRAS2 ZNF451
Entrez ID		54769	5910
HPRD ID		09711	11763
Ensembl ID		ENSG00000165023	ENSG00000138698
Uniprot IDs		Q96HU8	B3KNU0 P52306 Q6U7G8
PDB IDs		2ERX 6NAZ	5XGC 5ZHX
Enriched GO Terms of Interacting Partners?
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