RAP1GDS1 and DOC2A

Number of citations of the paper that reports this interaction (PubMedID 24722188)
63

Data Source:
BioGRID (two hybrid)

		RAP1GDS1	DOC2A
Description		Rap1 GTPase-GDP dissociation stimulator 1	double C2 domain alpha
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GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome	Nucleoplasm Nucleolus Lysosome Cell Junction Neuron Projection Extrinsic Component Of Synaptic Vesicle Membrane
	Molecular Function	GTPase Activator Activity Protein Binding	Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding
	Biological Process	Vascular Associated Smooth Muscle Contraction Myosin Filament Assembly Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of GTPase Activity Positive Regulation Of Mitochondrial Calcium Ion Concentration	Chemical Synaptic Transmission Nervous System Development Synaptic Vesicle Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Spontaneous Neurotransmitter Secretion
Pathways		RHOT2 GTPase cycle RHOT1 GTPase cycle
Drugs
Diseases
GWAS		Biochemical measures ( 19260141) Response to fenofibrate (total cholesterol levels) ( 27002377) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)	Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Height ( 28552196) Schizophrenia ( 28991256 25056061 29483656)
Interacting Genes		28 interacting genes: ABCB7 ANTXR2 CDC42 DIRAS1 DIRAS2 DOC2A EGFR HRAS KIFAP3 KRAS LEF1 MBIP MED28 NRAS OGT PLEKHB1 PTPRF PUF60 RAB6B RAC1 RAP1A RAP2B RAP2C RHOA RNF19B RRAS RRAS2 ZNF451	12 interacting genes: DYNLT1 EIF3C HS3ST4 RAP1GDS1 SCGN STXBP1 TAOK2 TBX6 TGFB1I1 TUFM UBASH3B UNC13B
Entrez ID		5910	8448
HPRD ID		11763	05195
Ensembl ID		ENSG00000138698	ENSG00000149927
Uniprot IDs		B3KNU0 P52306 Q6U7G8	Q14183
PDB IDs		5XGC 5ZHX	4MJJ
Enriched GO Terms of Interacting Partners?
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