RAP1GDS1 and RAP2C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		RAP1GDS1	RAP2C
Description		Rap1 GTPase-GDP dissociation stimulator 1	RAP2C, member of RAS oncogene family
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Cell-cell Contact Zone Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	GTPase Activator Activity Protein Binding	Transcription Coactivator Activity GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Vascular Associated Smooth Muscle Contraction Myosin Filament Assembly Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of GTPase Activity Positive Regulation Of Mitochondrial Calcium Ion Concentration	Microvillus Assembly Negative Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Positive Regulation Of Transcription, DNA-templated Regulation Of Protein Tyrosine Kinase Activity Establishment Of Endothelial Intestinal Barrier
Pathways		RHOT2 GTPase cycle RHOT1 GTPase cycle	Neutrophil degranulation
Drugs
Diseases
GWAS		Biochemical measures ( 19260141) Response to fenofibrate (total cholesterol levels) ( 27002377) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)	Gestational age at birth (maternal effect) ( 28877031) Uterine fibroids ( 31649266)
Interacting Genes		28 interacting genes: ABCB7 ANTXR2 CDC42 DIRAS1 DIRAS2 DOC2A EGFR HRAS KIFAP3 KRAS LEF1 MBIP MED28 NRAS OGT PLEKHB1 PTPRF PUF60 RAB6B RAC1 RAP1A RAP2B RAP2C RHOA RNF19B RRAS RRAS2 ZNF451	2 interacting genes: ADRB2 RAP1GDS1
Entrez ID		5910	57826
HPRD ID		11763	06706
Ensembl ID		ENSG00000138698	ENSG00000123728
Uniprot IDs		B3KNU0 P52306 Q6U7G8	A0A087X2C3 Q9Y3L5
PDB IDs		5XGC 5ZHX
Enriched GO Terms of Interacting Partners?
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