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PKD2 and PPP3CA
PKD2
PPP3CA
Description
polycystin 2, transient receptor potential cation channel
protein phosphatase 3 catalytic subunit alpha
Image
GO Annotations
Cellular Component
Polycystin Complex
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Cell-cell Junction
Cilium
Basal Plasma Membrane
Membrane
Basolateral Plasma Membrane
Lamellipodium
Cytoplasmic Vesicle Membrane
Motile Cilium
Cation Channel Complex
Ciliary Basal Body
Basal Cortex
Ciliary Membrane
Extracellular Exosome
Integral Component Of Cytoplasmic Side Of Endoplasmic Reticulum Membrane
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Mitotic Spindle
Non-motile Cilium
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Calcineurin Complex
Cytoplasmic Side Of Plasma Membrane
Extrinsic Component Of Plasma Membrane
Z Disc
Slit Diaphragm
Sarcolemma
Dendritic Spine
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Molecular Function
Signaling Receptor Binding
Voltage-gated Ion Channel Activity
Voltage-gated Calcium Channel Activity
Voltage-gated Sodium Channel Activity
Voltage-gated Potassium Channel Activity
Cation Channel Activity
Calcium Channel Activity
Potassium Channel Activity
Calcium Ion Binding
Protein Binding
Cytoskeletal Protein Binding
Outward Rectifier Potassium Channel Activity
Voltage-gated Cation Channel Activity
Identical Protein Binding
Protein Homodimerization Activity
Actinin Binding
HLH Domain Binding
Transmembrane Transporter Binding
Calcium-induced Calcium Release Activity
ATPase Binding
Phosphoprotein Binding
Muscle Alpha-actinin Binding
Protein Serine/threonine Phosphatase Activity
Calcium Ion Binding
Protein Binding
Calmodulin Binding
Cyclosporin A Binding
Enzyme Binding
Calmodulin-dependent Protein Phosphatase Activity
Protein-containing Complex Binding
Protein Dimerization Activity
ATPase Binding
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Biological Process
Branching Involved In Ureteric Bud Morphogenesis
Liver Development
Embryonic Placenta Development
Heart Looping
Detection Of Nodal Flow
Calcium Ion Transport
Receptor Signaling Pathway Via JAK-STAT
Determination Of Left/right Symmetry
Heart Development
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Wnt Signaling Pathway
Spinal Cord Development
Neural Tube Development
Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Cellular Response To Reactive Oxygen Species
Metanephric Part Of Ureteric Bud Development
Sodium Ion Transmembrane Transport
Aorta Development
Regulation Of Cell Population Proliferation
Cytoplasmic Sequestering Of Transcription Factor
Cilium Organization
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Transcription By RNA Polymerase II
Detection Of Mechanical Stimulus
Release Of Sequestered Calcium Ion Into Cytosol
Protein Tetramerization
Protein Homotetramerization
Protein Heterotetramerization
Centrosome Duplication
Regulation Of Cell Cycle
Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Placenta Blood Vessel Development
Renal Tubule Morphogenesis
Renal Artery Morphogenesis
Calcium Ion Transmembrane Transport
Cellular Response To Calcium Ion
Cellular Response To CAMP
Cellular Response To Hydrostatic Pressure
Cellular Response To Osmotic Stress
Cellular Response To Fluid Shear Stress
Potassium Ion Transmembrane Transport
Determination Of Liver Left/right Asymmetry
Metanephric Mesenchyme Development
Mesonephric Tubule Development
Mesonephric Duct Development
Metanephric Smooth Muscle Tissue Development
Metanephric Cortex Development
Metanephric Ascending Thin Limb Development
Metanephric Cortical Collecting Duct Development
Metanephric Distal Tubule Development
Metanephric S-shaped Body Morphogenesis
Regulation Of Calcium Ion Import
Inorganic Cation Transmembrane Transport
Cell-cell Signaling By Wnt
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
G1/S Transition Of Mitotic Cell Cycle
Response To Amphetamine
Protein Dephosphorylation
Protein Import Into Nucleus
Calcium Ion Transport
Brain Development
Aging
Transition Between Fast And Slow Fiber
Cardiac Muscle Hypertrophy In Response To Stress
Dephosphorylation
Positive Regulation Of Cell Migration
Calcineurin-NFAT Signaling Cascade
Multicellular Organismal Response To Stress
Negative Regulation Of Chromatin Binding
Wound Healing
T Cell Activation
Skeletal Muscle Tissue Regeneration
Positive Regulation Of Cell Adhesion
Positive Regulation Of Endocytosis
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Insulin Secretion
Skeletal Muscle Fiber Development
Negative Regulation Of Dendrite Morphogenesis
Positive Regulation Of DNA-binding Transcription Factor Activity
Response To Calcium Ion
Excitatory Postsynaptic Potential
Peptidyl-serine Dephosphorylation
Cellular Response To Glucose Stimulus
Calcineurin-mediated Signaling
Postsynaptic Modulation Of Chemical Synaptic Transmission
Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Positive Regulation Of Connective Tissue Replacement
Pathways
VxPx cargo-targeting to cilium
VxPx cargo-targeting to cilium
DARPP-32 events
Calcineurin activates NFAT
Calcineurin activates NFAT
FCERI mediated Ca+2 mobilization
Ca2+ pathway
CLEC7A (Dectin-1) induces NFAT activation
Drugs
Myristic acid
Diseases
GWAS
Coffee consumption (cups per day) (
25288136
)
Dental caries (
23064961
)
Gout (
30899057
)
Hyperuricemia (
28776340
)
Serum alkaline phosphatase levels (
33547301
)
Serum uric acid levels in response to allopurinol in gout (
25676789
)
Uric acid levels (
29558500
)
Adult body size (
32376654
)
Anorexia nervosa (
24514567
)
Bitter non-alcoholic beverage consumption (
31046077
)
Blood pressure (
22763476
)
Chronotype (
30696823
)
Corneal structure (
21979947
)
Trunk fat mass (
28552196
)
Vitiligo (
27723757
)
Interacting Genes
27 interacting genes:
ACTN2
ADH1A
ADH1C
CD2AP
CYSRT1
DIAPH1
HAX1
HSF2BP
KIF11
KRT40
KRTAP10-3
KRTAP10-8
KRTAP6-2
LMNA
MAGEA8
MDFI
MTAP
PACS1
PACS2
PKD1
PLSCR1
PPP3CA
PTPRG
TNNI3
TPM1
TRPC1
UCHL3
45 interacting genes:
AATK
ABI2
AKAP5
AMPH
ARMT1
ATP2B4
BAD
BCL2
C16orf74
CABIN1
CASP3
CRTC2
FAM167A
FGFR4
FKBP1A
FKBP8
GABRA1
GABRB2
GABRG2
GRB2
ITPKB
KCNIP3
KLHL3
MARCHF7
MYOZ2
MYOZ3
OGT
PKD2
PLAC8
PPP3R1
PPP3R2
PRKCZ
PTK7
RCAN1
RCAN2
RYK
SHANK2
SNCA
SOD1
STUB1
SYNJ1
TNS4
TRIM72
UBE4B
UNC119
Entrez ID
5311
5530
HPRD ID
01437
00234
Ensembl ID
ENSG00000118762
ENSG00000138814
Uniprot IDs
Q13563
Q9UEU6
A0A0S2Z4B5
A0A0S2Z4C6
Q08209
PDB IDs
2KLD
2KLE
2KQ6
2Y4Q
3HRN
3HRO
5K47
5MKE
5MKF
5T4D
6A70
6D1W
6T9N
6T9O
6WB8
1AUI
1M63
1MF8
2JOG
2JZI
2P6B
2R28
2W73
3LL8
4F0Z
4Q5U
5C1V
5SVE
6NUC
6NUF
6NUU
6UUQ
Enriched GO Terms of Interacting Partners
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