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PKD2 and HAX1
Number of citations of the paper that reports this interaction (PubMedID
10760273
)
39
Data Source:
HPRD
(in vivo, two hybrid)
PKD2
HAX1
Description
polycystin 2, transient receptor potential cation channel
HCLS1 associated protein X-1
Image
No pdb structure
GO Annotations
Cellular Component
Polycystin Complex
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Cell-cell Junction
Cilium
Basal Plasma Membrane
Membrane
Basolateral Plasma Membrane
Lamellipodium
Cytoplasmic Vesicle Membrane
Motile Cilium
Cation Channel Complex
Ciliary Basal Body
Basal Cortex
Ciliary Membrane
Extracellular Exosome
Integral Component Of Cytoplasmic Side Of Endoplasmic Reticulum Membrane
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Mitotic Spindle
Non-motile Cilium
P-body
Nuclear Envelope
Transcription Regulator Complex
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Intermembrane Space
Endoplasmic Reticulum
Cell Cortex
Actin Cytoskeleton
Apical Plasma Membrane
Sarcoplasmic Reticulum
Lamellipodium
Clathrin-coated Vesicle
Nuclear Membrane
Molecular Function
Signaling Receptor Binding
Voltage-gated Ion Channel Activity
Voltage-gated Calcium Channel Activity
Voltage-gated Sodium Channel Activity
Voltage-gated Potassium Channel Activity
Cation Channel Activity
Calcium Channel Activity
Potassium Channel Activity
Calcium Ion Binding
Protein Binding
Cytoskeletal Protein Binding
Outward Rectifier Potassium Channel Activity
Voltage-gated Cation Channel Activity
Identical Protein Binding
Protein Homodimerization Activity
Actinin Binding
HLH Domain Binding
Transmembrane Transporter Binding
Calcium-induced Calcium Release Activity
ATPase Binding
Phosphoprotein Binding
Muscle Alpha-actinin Binding
Protein Binding
Interleukin-1 Binding
Protein N-terminus Binding
Biological Process
Branching Involved In Ureteric Bud Morphogenesis
Liver Development
Embryonic Placenta Development
Heart Looping
Detection Of Nodal Flow
Calcium Ion Transport
Receptor Signaling Pathway Via JAK-STAT
Determination Of Left/right Symmetry
Heart Development
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Wnt Signaling Pathway
Spinal Cord Development
Neural Tube Development
Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Cellular Response To Reactive Oxygen Species
Metanephric Part Of Ureteric Bud Development
Sodium Ion Transmembrane Transport
Aorta Development
Regulation Of Cell Population Proliferation
Cytoplasmic Sequestering Of Transcription Factor
Cilium Organization
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Transcription By RNA Polymerase II
Detection Of Mechanical Stimulus
Release Of Sequestered Calcium Ion Into Cytosol
Protein Tetramerization
Protein Homotetramerization
Protein Heterotetramerization
Centrosome Duplication
Regulation Of Cell Cycle
Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Placenta Blood Vessel Development
Renal Tubule Morphogenesis
Renal Artery Morphogenesis
Calcium Ion Transmembrane Transport
Cellular Response To Calcium Ion
Cellular Response To CAMP
Cellular Response To Hydrostatic Pressure
Cellular Response To Osmotic Stress
Cellular Response To Fluid Shear Stress
Potassium Ion Transmembrane Transport
Determination Of Liver Left/right Asymmetry
Metanephric Mesenchyme Development
Mesonephric Tubule Development
Mesonephric Duct Development
Metanephric Smooth Muscle Tissue Development
Metanephric Cortex Development
Metanephric Ascending Thin Limb Development
Metanephric Cortical Collecting Duct Development
Metanephric Distal Tubule Development
Metanephric S-shaped Body Morphogenesis
Regulation Of Calcium Ion Import
Inorganic Cation Transmembrane Transport
Cell-cell Signaling By Wnt
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Mitochondrion Organization
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Regulation Of Actin Filament Polymerization
Positive Regulation Of Granulocyte Differentiation
Positive Regulation Of Peptidyl-serine Phosphorylation
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Protein Kinase B Signaling
Cellular Response To Cytokine Stimulus
Regulation Of Autophagy Of Mitochondrion
Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways
VxPx cargo-targeting to cilium
VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS
Coffee consumption (cups per day) (
25288136
)
Dental caries (
23064961
)
Gout (
30899057
)
Hyperuricemia (
28776340
)
Serum alkaline phosphatase levels (
33547301
)
Serum uric acid levels in response to allopurinol in gout (
25676789
)
Uric acid levels (
29558500
)
Bipolar disorder (
31043756
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Fish- and plant-related diet (
32066663
)
Mean spheric corpuscular volume (
32888494
)
Nicotine dependence (
28440896
)
Non-albumin protein levels (
29403010
)
Reticulocyte count (
32888494
)
Serum total protein level (
29403010
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Triglyceride levels (
32203549
)
Interacting Genes
27 interacting genes:
ACTN2
ADH1A
ADH1C
CD2AP
CYSRT1
DIAPH1
HAX1
HSF2BP
KIF11
KRT40
KRTAP10-3
KRTAP10-8
KRTAP6-2
LMNA
MAGEA8
MDFI
MTAP
PACS1
PACS2
PKD1
PLSCR1
PPP3CA
PTPRG
TNNI3
TPM1
TRPC1
UCHL3
28 interacting genes:
ABCB1
ABCB11
ABCB4
BIRC3
CTTN
DGKD
EIF3F
HCLS1
HNF4G
IL1A
KCNN3
KIAA0513
MAPK10
NEDD4L
PKD2
POLR1D
POLR1H
PPP3CC
PRNP
RBX1
RNF217
RPA1
STAT5B
SVIL
TCHH
UBAP2L
YWHAQ
ZNF420
Entrez ID
5311
10456
HPRD ID
01437
12075
Ensembl ID
ENSG00000118762
ENSG00000143575
Uniprot IDs
Q13563
Q9UEU6
A0A0S2Z565
A0A0S2Z591
O00165
PDB IDs
2KLD
2KLE
2KQ6
2Y4Q
3HRN
3HRO
5K47
5MKE
5MKF
5T4D
6A70
6D1W
6T9N
6T9O
6WB8
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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