PKD2 and KRTAP10-8

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		PKD2	KRTAP10-8
Description		polycystin 2, transient receptor potential cation channel	keratin associated protein 10-8
Image			No pdb structure
GO Annotations	Cellular Component	Polycystin Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cilium Basal Plasma Membrane Membrane Basolateral Plasma Membrane Lamellipodium Cytoplasmic Vesicle Membrane Motile Cilium Cation Channel Complex Ciliary Basal Body Basal Cortex Ciliary Membrane Extracellular Exosome Integral Component Of Cytoplasmic Side Of Endoplasmic Reticulum Membrane Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane Mitotic Spindle Non-motile Cilium	Cytosol Keratin Filament
	Molecular Function	Signaling Receptor Binding Voltage-gated Ion Channel Activity Voltage-gated Calcium Channel Activity Voltage-gated Sodium Channel Activity Voltage-gated Potassium Channel Activity Cation Channel Activity Calcium Channel Activity Potassium Channel Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Outward Rectifier Potassium Channel Activity Voltage-gated Cation Channel Activity Identical Protein Binding Protein Homodimerization Activity Actinin Binding HLH Domain Binding Transmembrane Transporter Binding Calcium-induced Calcium Release Activity ATPase Binding Phosphoprotein Binding Muscle Alpha-actinin Binding	Protein Binding Identical Protein Binding
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Liver Development Embryonic Placenta Development Heart Looping Detection Of Nodal Flow Calcium Ion Transport Receptor Signaling Pathway Via JAK-STAT Determination Of Left/right Symmetry Heart Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Wnt Signaling Pathway Spinal Cord Development Neural Tube Development Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Cellular Response To Reactive Oxygen Species Metanephric Part Of Ureteric Bud Development Sodium Ion Transmembrane Transport Aorta Development Regulation Of Cell Population Proliferation Cytoplasmic Sequestering Of Transcription Factor Cilium Organization Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Detection Of Mechanical Stimulus Release Of Sequestered Calcium Ion Into Cytosol Protein Tetramerization Protein Homotetramerization Protein Heterotetramerization Centrosome Duplication Regulation Of Cell Cycle Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Placenta Blood Vessel Development Renal Tubule Morphogenesis Renal Artery Morphogenesis Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To CAMP Cellular Response To Hydrostatic Pressure Cellular Response To Osmotic Stress Cellular Response To Fluid Shear Stress Potassium Ion Transmembrane Transport Determination Of Liver Left/right Asymmetry Metanephric Mesenchyme Development Mesonephric Tubule Development Mesonephric Duct Development Metanephric Smooth Muscle Tissue Development Metanephric Cortex Development Metanephric Ascending Thin Limb Development Metanephric Cortical Collecting Duct Development Metanephric Distal Tubule Development Metanephric S-shaped Body Morphogenesis Regulation Of Calcium Ion Import Inorganic Cation Transmembrane Transport Cell-cell Signaling By Wnt Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium	Keratinization
Drugs
Diseases
GWAS		Coffee consumption (cups per day) ( 25288136) Dental caries ( 23064961) Gout ( 30899057) Hyperuricemia ( 28776340) Serum alkaline phosphatase levels ( 33547301) Serum uric acid levels in response to allopurinol in gout ( 25676789) Uric acid levels ( 29558500)
Interacting Genes		27 interacting genes: ACTN2 ADH1A ADH1C CD2AP CYSRT1 DIAPH1 HAX1 HSF2BP KIF11 KRT40 KRTAP10-3 KRTAP10-8 KRTAP6-2 LMNA MAGEA8 MDFI MTAP PACS1 PACS2 PKD1 PLSCR1 PPP3CA PTPRG TNNI3 TPM1 TRPC1 UCHL3	388 interacting genes: - ACY3 ADAM12 ADAMTS1 ADAMTSL3 ADAMTSL4 AEBP2 AEN AK3 ALDH3B1 ALPI ALPP AMMECR1 ANKS1A AP1M1 APOL6 AQP1 AREG ARID5A ASPSCR1 ATG9A ATP5F1D AVPI1 AXIN2 BAHD1 BCL6B BEX2 BMP7 BRME1 C10orf62 C11orf87 C17orf50 C19orf25 C22orf39 C2orf68 C3 CAMK1G CARD10 CARHSP1 CATSPER1 CCDC26 CCNJL CHIC2 CHRD CHRNG CLK4 CNNM3 COL8A1 COX17 CRCT1 CREB5 CRH CRY2 CSF1 CTRC CYP2S1 CYSRT1 DAAM2 DCX DDX43 DDX55 DDX6 DERL2 DHRS1 DHX57 DMRT3 DOCK2 ECE1 EFEMP2 EIF4E2 ENKD1 EPDR1 FADS6 FAH FAM110A FAM161A FAM221B FAM27E3 FAM71C FAM74A4 FAM76B FAM90A1 FARS2 FBXO34 FBXW5 FEZF1 FOXB1 FRS3 FTHL17 FZD10 GEM GFOD1 GLIDR GLP1R GLRX3 GLYAT GNAI2 GNE GOLGA8EP GPANK1 GPHB5 GPRIN2 GRN GUCD1 HAPLN2 HCK HHEX HOXA1 HOXB5 HOXB9 HOXC8 HPCAL1 HS6ST1 HSD3B7 HSPA12B HSPD1 ICAM1 IGFBP6 IGSF8 IL10 IL16 IL2RG INO80B INTS5 IP6K3 ITGB2 ITGB4 ITGB5 JOSD1 JPH3 KLHL38 KLK8 KPRP KRT20 KRT83 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP15-1 KRTAP17-1 KRTAP19-7 KRTAP3-1 KRTAP3-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LAGE3 LASP1 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 LENG1 LINC00656 LMF2 LNX1 LRCH4 LRFN4 LUZP4 LYVE1 MACROH2A1 MAPKBP1 MATN3 MEIS2 MELTF MEOX2 MLLT6 MOBP MTA1 MUL1 MXI1 MYPOP NAB2 NAXD NBPF19 NECTIN2 NECTIN3 NEK6 NKD1 NOTCH2NLA NPDC1 NR1D2 NR4A3 NTN4 NUFIP2 OLIG3 OPCML OTX1 P2RX7 P2RY6 PAX5 PCED1A PCSK5 PDE9A PDIA4 PGAP6 PGLS PHLDA1 PIGS PIN1 PKD2 PLSCR4 POM121L8P POU1F1 POU4F2 PRKAB2 PRPF31 PRR13 PRR19 PTGER3 PTK7 PTPMT1 PTPRH PVR QPRT R3HDM2 RAB19 RAB3A RALGDS RANBP3 RASD1 RECK RGL2 RHBDL1 RHNO1 RNF38 RNF8 RPS19BP1 RPS28 RTN4RL1 SCARF1 SCNM1 SEMA3B SH3GLB2 SHFL SLC13A5 SLC22A23 SLC23A1 SLC25A10 SLC25A31 SLC25A42 SLC6A20 SLIT1 SMARCE1 SMCP SMG9 SMOC1 SPACA9 SPAG8 SPATA24 SPATA3 SPRY1 SPRY2 SSC4D STK16 SUSD2 SUSD6 SUV39H1 TACSTD2 TAPBPL TBC1D16 TBC1D23 TCAF1 TCEA2 TCEANC TFAP2D TGFB1 THAP10 THAP7 TIE1 TLE5 TMEM140 TMEM150A TMIE TNIP3 TNP2 TNPO3 TNS2 TRIM41 TRIM42 TRPV6 TSPAN4 TTC23 TXNDC5 TYMSOS TYRO3 UBL5 UTP23 UXT VASN VENTX VEZF1 VGLL3 VPS11 VWC2 VWC2L WIF1 WNT11 WT1 WT1-AS YIPF3 YY1 ZBTB24 ZBTB25 ZDHHC1 ZFYVE21 ZIC1 ZNF101 ZNF107 ZNF121 ZNF124 ZNF138 ZNF165 ZNF20 ZNF23 ZNF250 ZNF264 ZNF266 ZNF319 ZNF32 ZNF330 ZNF408 ZNF414 ZNF417 ZNF439 ZNF440 ZNF444 ZNF473 ZNF490 ZNF491 ZNF497 ZNF524 ZNF559 ZNF572 ZNF575 ZNF578 ZNF580 ZNF581 ZNF587 ZNF625 ZNF648 ZNF669 ZNF696 ZNF697 ZNF775 ZNF786 ZNF79 ZNF792 ZNF837 ZSCAN12 ZSCAN21
Entrez ID		5311	386681
HPRD ID		01437	11194
Ensembl ID		ENSG00000118762	ENSG00000187766
Uniprot IDs		Q13563 Q9UEU6	P60410
PDB IDs		2KLD 2KLE 2KQ6 2Y4Q 3HRN 3HRO 5K47 5MKE 5MKF 5T4D 6A70 6D1W 6T9N 6T9O 6WB8
Enriched GO Terms of Interacting Partners?
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