PIN1 and XRCC6

Number of citations of the paper that reports this interaction (PubMedID 16055720)
92

Data Source:
BioGRID (pull down)

		PIN1	XRCC6
Description		peptidylprolyl cis/trans isomerase, NIMA-interacting 1	X-ray repair cross complementing 6
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Nuclear Speck Midbody Ciliary Basal Body Neuron Projection Glutamatergic Synapse Postsynaptic Cytosol	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Extracellular Region Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytosol Membrane Protein-containing Complex Protein-DNA Complex Secretory Granule Lumen Ku70:Ku80 Complex Nonhomologous End Joining Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Cytoskeletal Motor Activity Protein Binding Beta-catenin Binding Cis-trans Isomerase Activity Mitogen-activated Protein Kinase Kinase Binding GTPase Activating Protein Binding Tau Protein Binding Phosphoserine Residue Binding Phosphothreonine Residue Binding Phosphoprotein Binding	Transcription Cis-regulatory Region Binding DNA Binding DNA Helicase Activity Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding RNA Binding Protein Binding ATP Binding Protein C-terminus Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity Cyclin Binding Telomeric DNA Binding Protein-containing Complex Binding DNA End Binding 5'-deoxyribose-5-phosphate Lyase Activity Scaffold Protein Binding
	Biological Process	Protein Peptidyl-prolyl Isomerization Response To Hypoxia Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Cell Cycle Regulation Of Mitotic Nuclear Division Regulation Of Gene Expression Neuron Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Stability Negative Regulation Of Protein Binding Positive Regulation Of Protein Binding Regulation Of Cytokinesis Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Positive Regulation Of Transcription By RNA Polymerase II Microtubule Polymerization Synapse Organization Protein Stabilization Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Localization To Nucleus Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Cell Motility	Telomere Maintenance Activation Of Innate Immune Response DNA Ligation Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Brain Development DNA Duplex Unwinding Innate Immune Response Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Smooth Muscle Cell Proliferation Cellular Hyperosmotic Salinity Response Cellular Response To Gamma Radiation Cellular Response To X-ray Double-strand Break Repair Via Classical Nonhomologous End Joining
Pathways		ISG15 antiviral mechanism RHO GTPases Activate NADPH Oxidases Regulation of TP53 Activity through Phosphorylation PI5P Regulates TP53 Acetylation Negative regulators of DDX58/IFIH1 signaling	2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation
Drugs		Beta-(2-Naphthyl)-Alanine 3,6,9,12,15,18-HEXAOXAICOSANE
Diseases
GWAS		Sleep duration ( 25469926)	Asthma ( 34103634) Breast cancer ( 29059683) Meat-related diet ( 32066663) Neuroticism ( 29255261) Pulse pressure ( 28135244) Refractive error ( 32231278)
Interacting Genes		263 interacting genes: ABI2 ADAMTSL4 ADARB1 AJUBA AMOT ANKRD40 AP2A1 APLP1 APP ARHGEF15 ARID5A ATCAY ATN1 ATP5F1B BAG6 BARD1 BCL11A BCL2 BCL6 BCLAF1 BRCA1 BRD8 C3orf36 CAPRIN1 CARHSP1 CASP6 CBFA2T3 CBS CBY2 CCDC153 CCDC184 CCDC33 CCDC6 CCDC88B CCDC90B CCNB1 CCNE1 CCNK CDC25C CDC27 CDK1 CDK11A CDK11B CDK12 CDK2 CDK9 CDKN1B CENPB CEP55 CEP76 CHAMP1 CHPF CNKSR1 COL11A2 CPEB1 CPNE6 CSAD CSNK2A1 CSNK2A2 CSNK2B CTNNB1 DAB1 DAB2 DDAH2 DDB1 DDX17 DDX24 DDX3X DDX5 DEAF1 DHX15 DMPK DYNC1I1 E2F4 EFS EFTUD2 EIF3G EP300 ETV6 EYA2 FAAP20 FADD FASLG FHL5 FOS FOSL1 FOXI1 FOXN1 FOXO4 FOXP2 FRS2 FUCA2 G3BP1 G3BP2 GGA2 GMEB2 GOLGA2 GOLGA6L9 GPAA1 GPHN GPR152 HADHA HEXIM2 HNRNPC HNRNPH1 HNRNPK HNRNPU HOMEZ HOXA1 IKZF1 IKZF3 INO80E JAKMIP2 JUN KCTD7 KIF20B KIF5A KIFC3 KLHL20 KMT2B KRT31 KRT34 KRT37 KRT38 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 LCN2 LEPR LRIF1 MAP1S MAP3K11 MAPT MCL1 MDFI MED1 MEOX1 MEOX2 MLLT6 MOCS1 MTFR1 MTUS2 MYF5 MYT1 NAB2 NCKIPSD NCOA3 NCOR2 NEK6 NELFA NEUROD4 NFATC2 NONO NR4A3 NUP35 NUP62 PABPC1 PAX6 PBX1 PDLIM7 PKIB PKM PKMYT1 PLAGL2 PLEKHG2 PLK1 PML PNMA1 POLR2A PRPF8 PRRC1 PTOV1 PTPN1 QARS1 RAB4A RAF1 RAI1 RARA RBBP8 RBBP8NL RBPMS RELA REPS1 RNF208 RNPS1 RPL4 RPS6KB1 RUNX2 SCAI SCYL1 SELENOV SFPQ SGK1 SHKBP1 SMAD3 SNCAIP SNRNP200 SOCS3 SREK1 SRRM1 SRRM2 SRSF11 SSBP2 SSBP3 SSBP4 SSC5D STIL SUPT5H TAB3 TBC1D4 TCF12 TCF4 TFG TFPT THAP7 THRAP3 TLE3 TNIP1 TNS2 TOP2A TOX3 TP53 TP63 TP73 TRAF1 TRAF2 TRIM27 TRIM59 TRIP6 TRMT2A TSC2 TSC22D4 TUT1 U2AF2 UBB UBQLN2 UBQLN4 UBXN2B UNC119 VIRMA WEE1 WIZ WRNIP1 XRCC6 ZBTB14 ZBTB2 ZBTB22 ZBTB42 ZBTB7B ZBTB9 ZCCHC10 ZMIZ2 ZNF446 ZNF449 ZNF526 ZNF768 ZNF783	135 interacting genes: ABCD4 ABL1 ACD ADCY7 APEX1 AR ARAP1 ATP23 ATP6V1E1 BARD1 BAZ1A BTG1 CAPN11 CBX5 CCNA1 CCT3 CD40 CDCA5 CDK2 CDKN1A CEBPA CENPU CHAF1A CHEK1 CLTC CLU CMTM6 COIL COPB1 CREBBP CSNK2A1 CTBP2 DLX2 DNTT DUX4 DYSF EFNA1 EGFR EID1 ELF3 EP300 EPS8 ETS1 FMNL1 GAL3ST4 GSE1 GZMA GZMB HERPUD1 HMGA2 HOXB7 HOXC4 HOXD4 HSF1 HTT ILVBL JPT2 KAT2A KAT2B KIAA0408 LIG3 MAP2K5 MAP4K2 MAPK8 MRE11 MSX2 NAA15 NCF4 NCL NCOA6 NIT1 NOTCH1 OGT PAEP PAFAH1B3 PARP1 PCNA PDK1 PDPK1 PDX1 PECAM1 PGAM1 PGR PIN1 PLGRKT PNRC2 POR POU2F1 POU2F2 PRKDC PRPF40A PTEN PTTG1 QRSL1 RASA1 RBBP4 RGS2 RNF126 RNF146 RPLP1 RPS10 RRAS2 RUNX2 SDHC SELENOF SERPINA2 SERPINB9 SET SGO1 SIRT3 SKIL SMAD3 SMAD7 SNTA1 SNU13 SPARC SUMO2 TAC1 TADA3 TBCD TCF4 TERF2 TERT TOP1 TP53 UBC USP14 VAV1 VBP1 WBP4 WRN XRCC5 YWHAZ ZBTB7A ZNF512B
Entrez ID		5300	2547
HPRD ID		03031	01071
Ensembl ID		ENSG00000127445	ENSG00000196419
Uniprot IDs		Q13526	A0A024R1N4 B1AHC9 B4DE32 B4E356 P12956
PDB IDs		1F8A 1I6C 1I8G 1I8H 1NMV 1NMW 1PIN 1ZCN 2F21 2ITK 2KBU 2KCF 2LB3 2M8I 2M8J 2M9E 2M9F 2M9I 2M9J 2N1O 2Q5A 2RUC 2RUD 2RUQ 2RUR 2XP3 2XP4 2XP5 2XP6 2XP7 2XP8 2XP9 2XPA 2XPB 2ZQS 2ZQT 2ZQU 2ZQV 2ZR4 2ZR5 2ZR6 3I6C 3IK8 3IKD 3IKG 3JYJ 3KAB 3KAC 3KAD 3KAF 3KAG 3KAH 3KAI 3KCE 3NTP 3ODK 3OOB 3TC5 3TCZ 3TDB 3WH0 4GWT 4GWV 4QIB 4TNS 4TYO 4U84 4U85 4U86 5B3W 5B3X 5B3Y 5B3Z 5BMY 5GPH 5UY9 5VTI 5VTJ 5VTK 6DUN 6O33 6O34 6SVC 6SVE 6SVH 6VAJ	1JEQ 1JEY 1JJR 3RZX 5Y3R 6ERF 6ERG 6ERH 6ZHA 6ZHE 7AXZ 7K0Y 7K1J 7K1K 7K1N
Enriched GO Terms of Interacting Partners?
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