XRCC6 and CCT3

Number of citations of the paper that reports this interaction (PubMedID 15383276)
151

Data Source:
HPRD (two hybrid)

		XRCC6	CCT3
Description		X-ray repair cross complementing 6	chaperonin containing TCP1 subunit 3
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Extracellular Region Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytosol Membrane Protein-containing Complex Protein-DNA Complex Secretory Granule Lumen Ku70:Ku80 Complex Nonhomologous End Joining Complex Ficolin-1-rich Granule Lumen	Zona Pellucida Receptor Complex Cytosol Chaperonin-containing T-complex Cytoskeleton Microtubule Cell Body Extracellular Exosome
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding DNA Helicase Activity Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding RNA Binding Protein Binding ATP Binding Protein C-terminus Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity Cyclin Binding Telomeric DNA Binding Protein-containing Complex Binding DNA End Binding 5'-deoxyribose-5-phosphate Lyase Activity Scaffold Protein Binding	RNA Binding Protein Binding ATP Binding Protein Folding Chaperone Unfolded Protein Binding
	Biological Process	Telomere Maintenance Activation Of Innate Immune Response DNA Ligation Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Brain Development DNA Duplex Unwinding Innate Immune Response Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Smooth Muscle Cell Proliferation Cellular Hyperosmotic Salinity Response Cellular Response To Gamma Radiation Cellular Response To X-ray Double-strand Break Repair Via Classical Nonhomologous End Joining	Protein Folding Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Pore Complex Assembly Protein Stabilization Toxin Transport Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation	Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs			Phosphoaminophosphonic Acid-Adenylate Ester Artenimol
Diseases
GWAS		Asthma ( 34103634) Breast cancer ( 29059683) Meat-related diet ( 32066663) Neuroticism ( 29255261) Pulse pressure ( 28135244) Refractive error ( 32231278)	Basophil count ( 32888494) Glycated hemoglobin levels ( 24647736) Household income (MTAG) ( 31844048) Mean corpuscular hemoglobin concentration ( 20139978) Mean corpuscular volume ( 29403010) Red blood cell count ( 29403010) Red cell distribution width ( 32888494) Subcutaneous adipose tissue ( 22589738) Walking pace ( 33128006)
Interacting Genes		135 interacting genes: ABCD4 ABL1 ACD ADCY7 APEX1 AR ARAP1 ATP23 ATP6V1E1 BARD1 BAZ1A BTG1 CAPN11 CBX5 CCNA1 CCT3 CD40 CDCA5 CDK2 CDKN1A CEBPA CENPU CHAF1A CHEK1 CLTC CLU CMTM6 COIL COPB1 CREBBP CSNK2A1 CTBP2 DLX2 DNTT DUX4 DYSF EFNA1 EGFR EID1 ELF3 EP300 EPS8 ETS1 FMNL1 GAL3ST4 GSE1 GZMA GZMB HERPUD1 HMGA2 HOXB7 HOXC4 HOXD4 HSF1 HTT ILVBL JPT2 KAT2A KAT2B KIAA0408 LIG3 MAP2K5 MAP4K2 MAPK8 MRE11 MSX2 NAA15 NCF4 NCL NCOA6 NIT1 NOTCH1 OGT PAEP PAFAH1B3 PARP1 PCNA PDK1 PDPK1 PDX1 PECAM1 PGAM1 PGR PIN1 PLGRKT PNRC2 POR POU2F1 POU2F2 PRKDC PRPF40A PTEN PTTG1 QRSL1 RASA1 RBBP4 RGS2 RNF126 RNF146 RPLP1 RPS10 RRAS2 RUNX2 SDHC SELENOF SERPINA2 SERPINB9 SET SGO1 SIRT3 SKIL SMAD3 SMAD7 SNTA1 SNU13 SPARC SUMO2 TAC1 TADA3 TBCD TCF4 TERF2 TERT TOP1 TP53 UBC USP14 VAV1 VBP1 WBP4 WRN XRCC5 YWHAZ ZBTB7A ZNF512B	26 interacting genes: BUD31 DEPDC5 EIF2B2 ERBB2 FANCA GEMIN4 HNRNPA0 HSPA8 LINC01554 LNX2 MAPK6 MIPOL1 OGT PAFAH1B2 PDCL POLR1C PTEN RAF1 SH3BP4 SHANK3 SUMO2 UBE2Z VAV2 VHL XRCC6 ZNRD2
Entrez ID		2547	7203
HPRD ID		01071	08969
Ensembl ID		ENSG00000196419	ENSG00000163468
Uniprot IDs		A0A024R1N4 B1AHC9 B4DE32 B4E356 P12956	B3KX11 P49368 Q59H77
PDB IDs		1JEQ 1JEY 1JJR 3RZX 5Y3R 6ERF 6ERG 6ERH 6ZHA 6ZHE 7AXZ 7K0Y 7K1J 7K1K 7K1N	6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8 7LUM 7LUP
Enriched GO Terms of Interacting Partners?
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