PIN1 and BCL11A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PIN1	BCL11A
Description		peptidylprolyl cis/trans isomerase, NIMA-interacting 1	BAF chromatin remodeling complex subunit BCL11A
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Nuclear Speck Midbody Ciliary Basal Body Neuron Projection Glutamatergic Synapse Postsynaptic Cytosol	Nucleus Nucleoplasm Chromosome Cytoplasm Postsynaptic Density Nuclear Matrix
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Cytoskeletal Motor Activity Protein Binding Beta-catenin Binding Cis-trans Isomerase Activity Mitogen-activated Protein Kinase Kinase Binding GTPase Activating Protein Binding Tau Protein Binding Phosphoserine Residue Binding Phosphothreonine Residue Binding Phosphoprotein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Kinase Binding Metal Ion Binding
	Biological Process	Protein Peptidyl-prolyl Isomerization Response To Hypoxia Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Cell Cycle Regulation Of Mitotic Nuclear Division Regulation Of Gene Expression Neuron Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Stability Negative Regulation Of Protein Binding Positive Regulation Of Protein Binding Regulation Of Cytokinesis Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Positive Regulation Of Transcription By RNA Polymerase II Microtubule Polymerization Synapse Organization Protein Stabilization Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Localization To Nucleus Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Cell Motility	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Protein Sumoylation Negative Regulation Of Dendrite Extension Negative Regulation Of Neuron Remodeling Cellular Response To L-glutamate Negative Regulation Of Dendrite Development Negative Regulation Of Branching Morphogenesis Of A Nerve
Pathways		ISG15 antiviral mechanism RHO GTPases Activate NADPH Oxidases Regulation of TP53 Activity through Phosphorylation PI5P Regulates TP53 Acetylation Negative regulators of DDX58/IFIH1 signaling	ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants
Drugs		Beta-(2-Naphthyl)-Alanine 3,6,9,12,15,18-HEXAOXAICOSANE
Diseases
GWAS		Sleep duration ( 25469926)	Acne (severe) ( 24927181 30542056) Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Attention deficit hyperactivity disorder ( 22012869) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Beta thalassemia/hemoglobin E disease ( 20183929) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Childhood absence epilepsy ( 30531953) Chronotype ( 30696823) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Epilepsy ( 30531953) F-cell distribution ( 17767159) F-cell distribution in sickle cell anaemia ( 21326311) Face memory ( 31596458) Falling risk ( 32999390) Fetal hemoglobin levels ( 18245381 20018918) Fetal hemoglobin levels in sickle cell anemia ( 25372704) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Generalized epilepsy ( 30531953) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heel bone mineral density ( 30598549) Hemoglobin A2 levels in sickle cell anemia ( 25042611) Hemoglobin levels ( 26366553) High fetal hemoglobin in sickle cell disease ( 27022141) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Household income (MTAG) ( 31844048) Hypersomnia (HLA-DQB1*06:02 negative) ( 23646285) Immature fraction of reticulocytes ( 32888494 27863252) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252 28017375 19862010) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Methadone dose in opioid dependence ( 28115739) Monocyte early outgrowth colony forming units ( 21493818) Morning person ( 30696823) Number of sexual partners ( 30643258) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Prostate-specific antigen levels ( 30410027 28139693) Red blood cell count ( 32888494 27863252) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252 28957414) Refractive error ( 32231278) Resting heart rate ( 27798624) Risk-taking tendency (4-domain principal component model) ( 30643258) Sickle cell anemia (haemolysis) ( 23406172) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 1 diabetes ( 34012112) Type 2 diabetes ( 22885922 24509480 29358691 30297969 32499647 20581827 30718926 28869590) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) Walking pace ( 33128006)
Interacting Genes		263 interacting genes: ABI2 ADAMTSL4 ADARB1 AJUBA AMOT ANKRD40 AP2A1 APLP1 APP ARHGEF15 ARID5A ATCAY ATN1 ATP5F1B BAG6 BARD1 BCL11A BCL2 BCL6 BCLAF1 BRCA1 BRD8 C3orf36 CAPRIN1 CARHSP1 CASP6 CBFA2T3 CBS CBY2 CCDC153 CCDC184 CCDC33 CCDC6 CCDC88B CCDC90B CCNB1 CCNE1 CCNK CDC25C CDC27 CDK1 CDK11A CDK11B CDK12 CDK2 CDK9 CDKN1B CENPB CEP55 CEP76 CHAMP1 CHPF CNKSR1 COL11A2 CPEB1 CPNE6 CSAD CSNK2A1 CSNK2A2 CSNK2B CTNNB1 DAB1 DAB2 DDAH2 DDB1 DDX17 DDX24 DDX3X DDX5 DEAF1 DHX15 DMPK DYNC1I1 E2F4 EFS EFTUD2 EIF3G EP300 ETV6 EYA2 FAAP20 FADD FASLG FHL5 FOS FOSL1 FOXI1 FOXN1 FOXO4 FOXP2 FRS2 FUCA2 G3BP1 G3BP2 GGA2 GMEB2 GOLGA2 GOLGA6L9 GPAA1 GPHN GPR152 HADHA HEXIM2 HNRNPC HNRNPH1 HNRNPK HNRNPU HOMEZ HOXA1 IKZF1 IKZF3 INO80E JAKMIP2 JUN KCTD7 KIF20B KIF5A KIFC3 KLHL20 KMT2B KRT31 KRT34 KRT37 KRT38 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 LCN2 LEPR LRIF1 MAP1S MAP3K11 MAPT MCL1 MDFI MED1 MEOX1 MEOX2 MLLT6 MOCS1 MTFR1 MTUS2 MYF5 MYT1 NAB2 NCKIPSD NCOA3 NCOR2 NEK6 NELFA NEUROD4 NFATC2 NONO NR4A3 NUP35 NUP62 PABPC1 PAX6 PBX1 PDLIM7 PKIB PKM PKMYT1 PLAGL2 PLEKHG2 PLK1 PML PNMA1 POLR2A PRPF8 PRRC1 PTOV1 PTPN1 QARS1 RAB4A RAF1 RAI1 RARA RBBP8 RBBP8NL RBPMS RELA REPS1 RNF208 RNPS1 RPL4 RPS6KB1 RUNX2 SCAI SCYL1 SELENOV SFPQ SGK1 SHKBP1 SMAD3 SNCAIP SNRNP200 SOCS3 SREK1 SRRM1 SRRM2 SRSF11 SSBP2 SSBP3 SSBP4 SSC5D STIL SUPT5H TAB3 TBC1D4 TCF12 TCF4 TFG TFPT THAP7 THRAP3 TLE3 TNIP1 TNS2 TOP2A TOX3 TP53 TP63 TP73 TRAF1 TRAF2 TRIM27 TRIM59 TRIP6 TRMT2A TSC2 TSC22D4 TUT1 U2AF2 UBB UBQLN2 UBQLN4 UBXN2B UNC119 VIRMA WEE1 WIZ WRNIP1 XRCC6 ZBTB14 ZBTB2 ZBTB22 ZBTB42 ZBTB7B ZBTB9 ZCCHC10 ZMIZ2 ZNF446 ZNF449 ZNF526 ZNF768 ZNF783	30 interacting genes: ACTC1 APP BCL6 CDCA3 CDK4 CDK6 EZH2 FXR2 GMCL2 HDAC1 HDAC2 LMO1 MORF4L2 MTA1 NCK2 NFAM1 NR2E3 NR2F1 NR2F2 NR2F6 PIN1 RBBP4 RBBP7 SIN3A SIRT1 SUZ12 TSC1 UBE2I YME1L1 ZBTB24
Entrez ID		5300	53335
HPRD ID		03031	05949
Ensembl ID		ENSG00000127445	ENSG00000119866
Uniprot IDs		Q13526	D9YZV9 D9YZW0 Q9H165
PDB IDs		1F8A 1I6C 1I8G 1I8H 1NMV 1NMW 1PIN 1ZCN 2F21 2ITK 2KBU 2KCF 2LB3 2M8I 2M8J 2M9E 2M9F 2M9I 2M9J 2N1O 2Q5A 2RUC 2RUD 2RUQ 2RUR 2XP3 2XP4 2XP5 2XP6 2XP7 2XP8 2XP9 2XPA 2XPB 2ZQS 2ZQT 2ZQU 2ZQV 2ZR4 2ZR5 2ZR6 3I6C 3IK8 3IKD 3IKG 3JYJ 3KAB 3KAC 3KAD 3KAF 3KAG 3KAH 3KAI 3KCE 3NTP 3ODK 3OOB 3TC5 3TCZ 3TDB 3WH0 4GWT 4GWV 4QIB 4TNS 4TYO 4U84 4U85 4U86 5B3W 5B3X 5B3Y 5B3Z 5BMY 5GPH 5UY9 5VTI 5VTJ 5VTK 6DUN 6O33 6O34 6SVC 6SVE 6SVH 6VAJ	5VTB 6KI6 6U9Q
Enriched GO Terms of Interacting Partners?
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