PHB and SMARCA2

Number of citations of the paper that reports this interaction (PubMedID 12065415)
44

Data Source:
HPRD (in vivo)

		PHB	SMARCA2
Description		prohibitin	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Mitochondrial Prohibitin Complex Extracellular Exosome	Chromatin Nucleus Nucleoplasm SWI/SNF Complex Intracellular Membrane-bounded Organelle Intermediate Filament Cytoskeleton NpBAF Complex NBAF Complex
	Molecular Function	Complement Component C3a Binding Complement Component C3b Binding Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Enzyme Binding Proteinase Activated Receptor Binding Histone Deacetylase Binding Protein Heterodimerization Activity	Transcription Cis-regulatory Region Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity Histone Binding ATP-dependent Chromatin Remodeler Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Positive Regulation Of Immunoglobulin Production Regulation Of Transcription, DNA-templated Mitochondrion Organization Signal Transduction Activation Of Phospholipase C Activity Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Cell Death Negative Regulation Of Transcription By Competitive Promoter Binding Histone Deacetylation CD40 Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Interleukin-17 Production RIG-I Signaling Pathway B Cell Activation Negative Regulation Of Protein Catabolic Process Regulation Of Apoptotic Process Modulation By Host Of Viral RNA Genome Replication Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Complement Activation Viral Entry Into Host Cell Positive Regulation Of Smooth Muscle Cell Proliferation Protein Stabilization Progesterone Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interleukin-6 DNA Biosynthetic Process T-helper 17 Type Immune Response Antiviral Innate Immune Response Positive Regulation Of NIK/NF-kappaB Signaling Activation Of Protein Kinase C Activity Negative Regulation Of Glucocorticoid Receptor Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Spermatid Development Nervous System Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Growth Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways		RAF activation Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF Processing of SMDT1 Signaling downstream of RAS mutants	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs		Rocaglamide Didesmethylrocaglamide
Diseases
GWAS		Asthma ( 31959851 30929738 32296059 29273806) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 31036433 30929738) Cancer ( 29299148) Coronary artery disease ( 29212778 33020668) Diastolic blood pressure ( 19430483 27841878) Lower body strength ( 27325353) Metabolite levels ( 23823483) Prostate cancer ( 23535732) Refractive error ( 32231278) Restricted and repetitive behaviours in autism spectrum disorder ( 28533516) Systolic blood pressure ( 27841878 30578418)	Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Asthma (childhood onset) ( 27611488) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Brain morphology (MOSTest) ( 32665545) Lead levels ( 26025379) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Monobrow ( 27182965) Neuritic plaque ( 31497858) Nose size ( 27182965) Parkinson's disease ( 26227905) Superior frontal gyrus grey matter volume ( 25335168) Systolic blood pressure ( 26969751) Thyroid volume in Hashimotoâ€™s thyroiditis ( 32019955)
Interacting Genes		27 interacting genes: ANXA2 BCAS3 CASC3 CCL5 COX6C E2F1 ESR1 HDAC1 LONRF3 MAP1LC3A MAP3K10 MCM2 NCOR1 PTEN RAF1 RB1 RBL1 RBL2 SEC22A SIN3A SMARCA2 SMARCA4 ST14 SUMO4 TP53 TUBG1 XPO1	54 interacting genes: ACTL6A ACTL6B ACTN2 ANO10 APC2 AR ARID1B BEND7 BRCA1 CCDC136 CEBPA CEP72 CNTROB CXXC1 DAB2IP DNM2 ESR1 GAPDH GCC1 GFAP H3C1 HSPB1 ITPRID2 KHDRBS1 LAMC1 MDM2 MDM4 MECP2 MPRIP MYB MYC MYO5B NECAB2 NR0B2 NR3C1 NR4A2 NUP62 PHB PICK1 PITX1 PPFIA2 PPP1R12C PRMT5 PRPF6 RAP1A SDCBP SIN3B SMARCC2 SPAG5 SS18 SUPT4H1 TACC2 TNFAIP1 ZNF821
Entrez ID		5245	6595
HPRD ID		01454	02483
Ensembl ID		ENSG00000167085	ENSG00000080503
Uniprot IDs		A8K401 P35232 Q53FV0	B1ALF6 B4DNT1 B4DSC8 F6T8Q0 F6VDE0 P51531 Q56A76 Q8N9Q1
PDB IDs		1LU7	2DAT 4QY4 5DKC 5DKH 6EG2 6EG3 6HAX 6HAY 6HAZ
Enriched GO Terms of Interacting Partners?
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