SMARCA2 and DAB2IP

Number of citations of the paper that reports this interaction (PubMedID 21653829)
98

Data Source:
BioGRID (two hybrid)

		SMARCA2	DAB2IP
Description		SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	DAB2 interacting protein
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm SWI/SNF Complex Intracellular Membrane-bounded Organelle Intermediate Filament Cytoskeleton NpBAF Complex NBAF Complex	Cytoplasm Cytosol Plasma Membrane Endocytic Vesicle Axon Dendrite Neuronal Cell Body Membrane Neuronal Cell Body Cerebellar Mossy Fiber Climbing Fiber Parallel Fiber AIP1-IRE1 Complex
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity Histone Binding ATP-dependent Chromatin Remodeler Activity	GTPase Activator Activity Death Receptor Binding Protein Binding SH3 Domain Binding Kinase Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Phosphatidylinositol-3-phosphate Binding Signaling Adaptor Activity Toll-like Receptor 4 Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Identical Protein Binding Protein Homodimerization Activity Vascular Endothelial Growth Factor Receptor 2 Binding Protein Serine/threonine Kinase Activator Activity Phosphatidylinositol 3-kinase Binding Protein-containing Complex Binding Cadherin Binding Protein Phosphatase 2A Binding Phosphatidylinositol-4-phosphate Binding 14-3-3 Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Spermatid Development Nervous System Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Growth Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Negative Regulation Of Protein Phosphorylation Inflammatory Response Cell Cycle I-kappaB Phosphorylation Negative Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Neuron Projection Development Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Angiogenesis Cell Motility Involved In Cerebral Cortex Radial Glia Guided Migration Layer Formation In Cerebral Cortex Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of GTPase Activity Cellular Response To Unfolded Protein Tube Formation Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Reelin-mediated Signaling Pathway Regulation Of Growth Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein-containing Complex Assembly Negative Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Negative Regulation Of Phosphatidylinositol 3-kinase Activity Cellular Protein Catabolic Process Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Fibroblast Proliferation Neuron Projection Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of G0 To G1 Transition Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Endothelial Cell Apoptotic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Synapse Maturation Positive Regulation Of Dendrite Development Regulation Of P38MAPK Cascade Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Cellular Protein Catabolic Process Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Neuron Migration Positive Regulation Of Apoptotic Signaling Pathway
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	Regulation of RAS by GAPs
Drugs
Diseases
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Asthma (childhood onset) ( 27611488) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Brain morphology (MOSTest) ( 32665545) Lead levels ( 26025379) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Monobrow ( 27182965) Neuritic plaque ( 31497858) Nose size ( 27182965) Parkinson's disease ( 26227905) Superior frontal gyrus grey matter volume ( 25335168) Systolic blood pressure ( 26969751) Thyroid volume in Hashimotoâ€™s thyroiditis ( 32019955)	Abdominal aortic aneurysm ( 27899403 20622881) Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) ( 23648065) Arterial stiffness index ( 31235810) Coronary artery disease ( 32469254 29212778 33020668) Heart rate ( 23534349) Hip index ( 34021172) Metabolite levels ( 23823483) Metabolite levels (X-11787) ( 23934736) Myocardial infarction ( 33532862) Periodontal microbiota ( 22699663) Squamous cell lung carcinoma ( 31326317) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) vWF levels ( 30586737) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		54 interacting genes: ACTL6A ACTL6B ACTN2 ANO10 APC2 AR ARID1B BEND7 BRCA1 CCDC136 CEBPA CEP72 CNTROB CXXC1 DAB2IP DNM2 ESR1 GAPDH GCC1 GFAP H3C1 HSPB1 ITPRID2 KHDRBS1 LAMC1 MDM2 MDM4 MECP2 MPRIP MYB MYC MYO5B NECAB2 NR0B2 NR3C1 NR4A2 NUP62 PHB PICK1 PITX1 PPFIA2 PPP1R12C PRMT5 PRPF6 RAP1A SDCBP SIN3B SMARCC2 SPAG5 SS18 SUPT4H1 TACC2 TNFAIP1 ZNF821	7 interacting genes: AKT1 ANKS1A DAB1 DAB2 MAP3K5 SMARCA2 YWHAQ
Entrez ID		6595	153090
HPRD ID		02483	09903
Ensembl ID		ENSG00000080503	ENSG00000136848
Uniprot IDs		B1ALF6 B4DNT1 B4DSC8 F6T8Q0 F6VDE0 P51531 Q56A76 Q8N9Q1	Q5VWQ8
PDB IDs		2DAT 4QY4 5DKC 5DKH 6EG2 6EG3 6HAX 6HAY 6HAZ
Enriched GO Terms of Interacting Partners?
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