PHB and ANXA2

Number of citations of the paper that reports this interaction (PubMedID 12628297)
8

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		PHB	ANXA2
Description		prohibitin	annexin A2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Mitochondrial Prohibitin Complex Extracellular Exosome	Ruffle Extracellular Region Basement Membrane Extracellular Space Nucleus Cytoplasm Lysosomal Membrane Endosome Early Endosome Lipid Droplet Cytosol Plasma Membrane Adherens Junction Cell Cortex Cell Surface Membrane Basolateral Plasma Membrane Extrinsic Component Of Plasma Membrane Midbody Late Endosome Membrane Vesicle Azurophil Granule Lumen Myelin Sheath Adaxonal Region Sarcolemma Melanosome Schmidt-Lanterman Incisure Macropinosome Membrane Raft Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome AnxA2-p11 Complex PCSK9-AnxA2 Complex
	Molecular Function	Complement Component C3a Binding Complement Component C3b Binding Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Enzyme Binding Proteinase Activated Receptor Binding Histone Deacetylase Binding Protein Heterodimerization Activity	Phosphatidylserine Binding Protease Binding RNA Binding Serine-type Endopeptidase Inhibitor Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Phospholipase A2 Inhibitor Activity Small GTPase Binding Identical Protein Binding S100 Protein Binding Bone Sialoprotein Binding Virion Binding Calcium-dependent Protein Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Positive Regulation Of Immunoglobulin Production Regulation Of Transcription, DNA-templated Mitochondrion Organization Signal Transduction Activation Of Phospholipase C Activity Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Cell Death Negative Regulation Of Transcription By Competitive Promoter Binding Histone Deacetylation CD40 Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Interleukin-17 Production RIG-I Signaling Pathway B Cell Activation Negative Regulation Of Protein Catabolic Process Regulation Of Apoptotic Process Modulation By Host Of Viral RNA Genome Replication Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Complement Activation Viral Entry Into Host Cell Positive Regulation Of Smooth Muscle Cell Proliferation Protein Stabilization Progesterone Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interleukin-6 DNA Biosynthetic Process T-helper 17 Type Immune Response Antiviral Innate Immune Response Positive Regulation Of NIK/NF-kappaB Signaling Activation Of Protein Kinase C Activity Negative Regulation Of Glucocorticoid Receptor Signaling Pathway	Angiogenesis Membrane Raft Assembly Positive Regulation Of Receptor Recycling Positive Regulation Of Protein Phosphorylation Vesicle Budding From Membrane Body Fluid Secretion Negative Regulation Of Endopeptidase Activity Collagen Fibril Organization Positive Regulation Of Vesicle Fusion Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Osteoclast Development Fibrinolysis Positive Regulation Of Vacuole Organization Positive Regulation Of Fibroblast Proliferation Calcium Ion Transmembrane Transport Protein Localization To Plasma Membrane Response To Thyroid Hormone Cell-cell Adhesion Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Low-density Lipoprotein Receptor Activity Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport
Pathways		RAF activation Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF Processing of SMDT1 Signaling downstream of RAS mutants	Smooth Muscle Contraction Neutrophil degranulation Dissolution of Fibrin Clot Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Rocaglamide Didesmethylrocaglamide	Tenecteplase Fluocinolone acetonide Lanoteplase Artenimol
Diseases
GWAS		Asthma ( 31959851 30929738 32296059 29273806) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 31036433 30929738) Cancer ( 29299148) Coronary artery disease ( 29212778 33020668) Diastolic blood pressure ( 19430483 27841878) Lower body strength ( 27325353) Metabolite levels ( 23823483) Prostate cancer ( 23535732) Refractive error ( 32231278) Restricted and repetitive behaviours in autism spectrum disorder ( 28533516) Systolic blood pressure ( 27841878 30578418)	Asthma ( 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Blood protein levels ( 30072576 28240269) Night sleep phenotypes ( 27126917) Type 2 diabetes ( 25102180)
Interacting Genes		27 interacting genes: ANXA2 BCAS3 CASC3 CCL5 COX6C E2F1 ESR1 HDAC1 LONRF3 MAP1LC3A MAP3K10 MCM2 NCOR1 PTEN RAF1 RB1 RBL1 RBL2 SEC22A SIN3A SMARCA2 SMARCA4 ST14 SUMO4 TP53 TUBG1 XPO1	46 interacting genes: ACTA1 APOH APP CCDC32 CD99 CDC42 CEACAM1 CTSB CTSS DYSF GRB2 HMGA1 LGALS13 LINC01554 LYPLA1 MAP3K4 MYOC NOD2 OGDH PHB PLA1A PLA2G4A PLAT PLG POT1 PRKCA PRKCB PTEN RPS2 S100A10 S100A4 S100A6 SLC26A4-AS1 SMAD6 SMN1 SNX17 SOS1 SRC STAT6 TENT2 TERF1 TERT TNC TRPV5 YWHAQ ZBTB4
Entrez ID		5245	302
HPRD ID		01454	01061
Ensembl ID		ENSG00000167085	ENSG00000182718
Uniprot IDs		A8K401 P35232 Q53FV0	A0A024R5Z7 H0YL33 P07355
PDB IDs		1LU7	1W7B 1XJL 2HYU 2HYV 2HYW 4DRW 4FTG 4HRH 5LPU 5LPX 5LQ0 5LQ2 5N7D 5N7F 5N7G 6TWQ 6TWU 6TWX 6TWY
Enriched GO Terms of Interacting Partners?
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