ANXA2 and CEACAM1

Number of citations of the paper that reports this interaction (PubMedID 14522961)
18

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		ANXA2	CEACAM1
Description		annexin A2	CEA cell adhesion molecule 1
Image
GO Annotations	Cellular Component	Ruffle Extracellular Region Basement Membrane Extracellular Space Nucleus Cytoplasm Lysosomal Membrane Endosome Early Endosome Lipid Droplet Cytosol Plasma Membrane Adherens Junction Cell Cortex Cell Surface Membrane Basolateral Plasma Membrane Extrinsic Component Of Plasma Membrane Midbody Late Endosome Membrane Vesicle Azurophil Granule Lumen Myelin Sheath Adaxonal Region Sarcolemma Melanosome Schmidt-Lanterman Incisure Macropinosome Membrane Raft Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome AnxA2-p11 Complex PCSK9-AnxA2 Complex	Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Adherens Junction Basal Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Apical Plasma Membrane Lateral Plasma Membrane Cell Junction Transport Vesicle Membrane Microvillus Membrane Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	Phosphatidylserine Binding Protease Binding RNA Binding Serine-type Endopeptidase Inhibitor Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Phospholipase A2 Inhibitor Activity Small GTPase Binding Identical Protein Binding S100 Protein Binding Bone Sialoprotein Binding Virion Binding Calcium-dependent Protein Binding Cadherin Binding Involved In Cell-cell Adhesion	Molecular_function Actin Binding Protein Binding Calmodulin Binding Bile Acid Transmembrane Transporter Activity Kinase Binding Protein Phosphatase Binding Filamin Binding Identical Protein Binding Protein Homodimerization Activity Protein Dimerization Activity Protein Tyrosine Kinase Binding
	Biological Process	Angiogenesis Membrane Raft Assembly Positive Regulation Of Receptor Recycling Positive Regulation Of Protein Phosphorylation Vesicle Budding From Membrane Body Fluid Secretion Negative Regulation Of Endopeptidase Activity Collagen Fibril Organization Positive Regulation Of Vesicle Fusion Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Osteoclast Development Fibrinolysis Positive Regulation Of Vacuole Organization Positive Regulation Of Fibroblast Proliferation Calcium Ion Transmembrane Transport Protein Localization To Plasma Membrane Response To Thyroid Hormone Cell-cell Adhesion Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Low-density Lipoprotein Receptor Activity Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport	Angiogenesis Regulation Of Cell Growth Blood Vessel Development Negative Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Negative Regulation Of Protein Kinase Activity Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Integrin-mediated Signaling Pathway Regulation Of Endothelial Cell Migration Regulation Of Phosphatidylinositol 3-kinase Signaling Bile Acid And Bile Salt Transport Cell Migration Regulation Of Cell Migration Negative Regulation Of Granulocyte Differentiation Negative Regulation Of Interleukin-1 Production Cellular Response To Insulin Stimulus Common Myeloid Progenitor Cell Proliferation Insulin Receptor Internalization Granulocyte Colony-stimulating Factor Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Vascular Permeability Negative Regulation Of Cytotoxic T Cell Degranulation Wound Healing, Spreading Of Cells Regulation Of Endothelial Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Lipid Biosynthetic Process Regulation Of Blood Vessel Remodeling Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Platelet Aggregation Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Insulin Catabolic Process Regulation Of Homophilic Cell Adhesion Regulation Of Sprouting Angiogenesis Negative Regulation Of Hepatocyte Proliferation Positive Regulation Of Vasculogenesis
Pathways		Smooth Muscle Contraction Neutrophil degranulation Dissolution of Fibrin Clot Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Fibronectin matrix formation Cell surface interactions at the vascular wall Neutrophil degranulation
Drugs		Tenecteplase Fluocinolone acetonide Lanoteplase Artenimol	Technetium Tc-99m arcitumomab
Diseases
GWAS		Asthma ( 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Blood protein levels ( 30072576 28240269) Night sleep phenotypes ( 27126917) Type 2 diabetes ( 25102180)
Interacting Genes		46 interacting genes: ACTA1 APOH APP CCDC32 CD99 CDC42 CEACAM1 CTSB CTSS DYSF GRB2 HMGA1 LGALS13 LINC01554 LYPLA1 MAP3K4 MYOC NOD2 OGDH PHB PLA1A PLA2G4A PLAT PLG POT1 PRKCA PRKCB PTEN RPS2 S100A10 S100A4 S100A6 SLC26A4-AS1 SMAD6 SMN1 SNX17 SOS1 SRC STAT6 TENT2 TERF1 TERT TNC TRPV5 YWHAQ ZBTB4	19 interacting genes: ADRB2 ANXA2 APOE CARTPT CD209 CEACAM3 CEACAM5 CEACAM6 CEACAM7 CEACAM8 EGFR FLNA INSR MAP3K10 PTPN11 PTPN6 PXN SHC1 SRC
Entrez ID		302	634
HPRD ID		01061	00191
Ensembl ID		ENSG00000182718	ENSG00000079385
Uniprot IDs		A0A024R5Z7 H0YL33 P07355	P13688 Q3KRG8
PDB IDs		1W7B 1XJL 2HYU 2HYV 2HYW 4DRW 4FTG 4HRH 5LPU 5LPX 5LQ0 5LQ2 5N7D 5N7F 5N7G 6TWQ 6TWU 6TWX 6TWY	2GK2 4QXW 4WHD 5DZL 6AW2 6GBG 6GBH 6V3P
Enriched GO Terms of Interacting Partners?
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