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NLK and LEF1
Number of citations of the paper that reports this interaction (PubMedID
12556497
)
87
Data Source:
HPRD
(in vitro, in vivo)
NLK
LEF1
Description
nemo like kinase
lymphoid enhancer binding factor 1
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Protein-DNA Complex
Beta-catenin-TCF Complex
Molecular Function
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
Protein Binding
ATP Binding
Transcription Factor Binding
Ubiquitin Protein Ligase Binding
SH2 Domain Binding
Protein Serine Kinase Activity
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Beta-catenin Binding
DNA Binding, Bending
Estrogen Receptor Binding
Histone Binding
Histone Deacetylase Binding
Sequence-specific DNA Binding
Gamma-catenin Binding
Armadillo Repeat Domain Binding
C2H2 Zinc Finger Domain Binding
Transcription Regulator Inhibitor Activity
Sequence-specific Double-stranded DNA Binding
Biological Process
MAPK Cascade
Regulation Of Transcription, DNA-templated
Protein Phosphorylation
Transforming Growth Factor Beta Receptor Signaling Pathway
Wnt Signaling Pathway, Calcium Modulating Pathway
Peptidyl-threonine Phosphorylation
Negative Regulation Of Wnt Signaling Pathway
Intracellular Signal Transduction
Serine Phosphorylation Of STAT Protein
Protein Autophosphorylation
Protein Stabilization
Negative Regulation Of Transcription By RNA Polymerase II
Branching Involved In Blood Vessel Morphogenesis
Osteoblast Differentiation
Somitogenesis
Epithelial To Mesenchymal Transition
Sprouting Angiogenesis
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Positive Regulation Of Epithelial To Mesenchymal Transition
Dentate Gyrus Development
Forebrain Radial Glial Cell Differentiation
Forebrain Neuroblast Division
Formation Of Radial Glial Scaffolds
Positive Regulation Of Wnt Signaling Pathway
Neutrophil Differentiation
Embryonic Limb Morphogenesis
Positive Regulation Of Cell Migration
BMP Signaling Pathway
Positive Regulation Of Granulocyte Differentiation
Mammary Gland Development
Negative Regulation Of Interleukin-13 Production
Negative Regulation Of Interleukin-4 Production
Negative Regulation Of Interleukin-5 Production
T Cell Receptor V(D)J Recombination
B Cell Proliferation
Odontogenesis Of Dentin-containing Tooth
Negative Regulation Of Apoptotic Process
Negative Regulation Of DNA Binding
Tongue Development
Positive Regulation By Host Of Viral Transcription
Histone H3 Acetylation
Histone H4 Acetylation
T-helper 1 Cell Differentiation
Positive Regulation Of Gamma-delta T Cell Differentiation
Negative Regulation Of Striated Muscle Tissue Development
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Paraxial Mesoderm Formation
Sensory Perception Of Taste
Anatomical Structure Regression
Canonical Wnt Signaling Pathway
Face Morphogenesis
Cell Chemotaxis
Chorio-allantoic Fusion
Trachea Gland Development
Secondary Palate Development
Cellular Response To Cytokine Stimulus
Cellular Response To Interleukin-4
Positive Regulation Of Cell Proliferation In Bone Marrow
Negative Regulation Of Apoptotic Process In Bone Marrow Cell
Histone H3-K56 Acetylation
Apoptotic Process Involved In Blood Vessel Morphogenesis
Positive Regulation Of Chondrocyte Proliferation
Pathways
Ca2+ pathway
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex
Ca2+ pathway
Binding of TCF/LEF:CTNNB1 to target gene promoters
Repression of WNT target genes
Repression of WNT target genes
Transcriptional Regulation by VENTX
RUNX3 regulates WNT signaling
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
Drugs
Etacrynic acid
Diseases
GWAS
Non-response to bupropion and depression (
27622933
)
Airflow obstruction (
22837378
)
Blond vs. brown/black hair color (
30531825
)
Chronic lymphocytic leukemia (
28165464
26956414
23770605
)
Diastolic blood pressure (
27841878
)
Medication use (calcium channel blockers) (
31015401
)
Metabolic traits (
19060910
)
Multiple sclerosis (
31604244
)
Systemic lupus erythematosus (
22291604
)
Systolic blood pressure (
27841878
30578418
)
Tooth agenesis (mandibular second premolars) (
29364747
)
Interacting Genes
25 interacting genes:
ASGR1
ATXN1
CREBBP
CUL1
FBXW5
FOXO4
FOXP3
GRN
HIPK2
KRTAP10-1
KRTAP10-3
KRTAP4-2
KRTAP5-6
KRTAP5-9
LEF1
MYB
MYBL1
NDOR1
QRICH1
RCHY1
SDR16C5
SKP2
STAT3
USP4
ZHX3
35 interacting genes:
ALX4
ALYREF
AURKA
BAX
BUB1
CDX1
CTNNB1
DPYSL2
EP300
KPNA1
KPNA2
MITF
MLH1
MLH3
MSH2
NFE2L2
NLK
NOTCH1
NRAS
PIAS4
PITX2
RAP1GDS1
RB1
RUNX2
SMAD1
SMAD2
SMAD3
SMAD4
STK11
SUMO2
TLE1
TLE2
TRA
UBTF
ZBTB3
Entrez ID
51701
51176
HPRD ID
17637
01075
Ensembl ID
ENSG00000087095
ENSG00000138795
Uniprot IDs
A0A024QZ12
Q9UBE8
Q659G9
Q9UJU2
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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