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NLK and CUL1
Number of citations of the paper that reports this interaction (PubMedID
18765672
)
29
Data Source:
HPRD
(in vivo)
NLK
CUL1
Description
nemo like kinase
cullin 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Nucleoplasm
Cytosol
Plasma Membrane
SCF Ubiquitin Ligase Complex
Cullin-RING Ubiquitin Ligase Complex
Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
Molecular Function
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
Protein Binding
ATP Binding
Transcription Factor Binding
Ubiquitin Protein Ligase Binding
SH2 Domain Binding
Protein Serine Kinase Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Biological Process
MAPK Cascade
Regulation Of Transcription, DNA-templated
Protein Phosphorylation
Transforming Growth Factor Beta Receptor Signaling Pathway
Wnt Signaling Pathway, Calcium Modulating Pathway
Peptidyl-threonine Phosphorylation
Negative Regulation Of Wnt Signaling Pathway
Intracellular Signal Transduction
Serine Phosphorylation Of STAT Protein
Protein Autophosphorylation
Protein Stabilization
G1/S Transition Of Mitotic Cell Cycle
Protein Monoubiquitination
Cell Population Proliferation
Animal Organ Morphogenesis
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein K48-linked Ubiquitination
Intrinsic Apoptotic Signaling Pathway
Pathways
Ca2+ pathway
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
NOTCH1 Intracellular Domain Regulates Transcription
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Circadian Clock
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Orc1 removal from chromatin
Cyclin D associated events in G1
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Neddylation
Interleukin-1 signaling
Iron uptake and transport
Negative regulation of NOTCH4 signaling
Regulation of BACH1 activity
Nuclear events stimulated by ALK signaling in cancer
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Non-response to bupropion and depression (
27622933
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Uterine fibroid size (maximum volume) (
30196971
)
Interacting Genes
25 interacting genes:
ASGR1
ATXN1
CREBBP
CUL1
FBXW5
FOXO4
FOXP3
GRN
HIPK2
KRTAP10-1
KRTAP10-3
KRTAP4-2
KRTAP5-6
KRTAP5-9
LEF1
MYB
MYBL1
NDOR1
QRICH1
RCHY1
SDR16C5
SKP2
STAT3
USP4
ZHX3
57 interacting genes:
BTRC
CAND1
CDC34
CDCA3
CDK9
CDKN1B
CENPE
CENPW
CFLAR
CHEK1
CHUK
CKS1B
COMMD1
COPS5
COPS6
COPS8
DLEU2
E2F1
FBH1
FBXO25
FBXW11
FBXW2
FBXW4
FBXW7
GHR
GPS1
HIPK2
KHNYN
NEDD8
NFKBIA
NFKBIB
NFKBIE
NLK
NLRP3
NR1D2
PPP1CA
PRKN
PRPF40A
PSMB4
PSMD4
PTTG1
RAC2
RANBP2
RBX1
RICTOR
RNF7
SENP8
SKP1
SKP2
SMAD3
THRA
TRIM21
UBC
UBE2E3
UBE2F
UBE2M
ZC3HC1
Entrez ID
51701
8454
HPRD ID
17637
04389
Ensembl ID
ENSG00000087095
ENSG00000055130
Uniprot IDs
A0A024QZ12
Q9UBE8
A0A090N7U0
B3KTW0
Q13616
PDB IDs
1LDJ
1LDK
1U6G
3RTR
3TDU
3TDZ
4F52
4P5O
5V89
6TTU
6WCQ
7B5L
7B5M
7B5N
7B5R
7B5S
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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