OAS3 and IFRD2

Number of citations of the paper that reports this interaction (PubMedID 21903422)
143

Data Source:
BioGRID (affinity chromatography technology, pull down)

		OAS3	IFRD2
Description		2'-5'-oligoadenylate synthetase 3	interferon related developmental regulator 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Intracellular Membrane-bounded Organelle	Nucleus
	Molecular Function	2'-5'-oligoadenylate Synthetase Activity Double-stranded RNA Binding Protein Binding ATP Binding Metal Ion Binding	Molecular_function Protein Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Response To Virus Positive Regulation Of Interferon-beta Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Chemokine (C-X-C Motif) Ligand 9 Production RIG-I Signaling Pathway MDA-5 Signaling Pathway Defense Response To Bacterium Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Negative Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Ribonuclease Activity Positive Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Negative Regulation Of IP-10 Production Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		Interferon gamma signaling OAS antiviral response Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Alcohol consumption ( 21270382) Alcohol consumption (drinkers vs non-drinkers) ( 28485404) Body mass index ( 26426971) Chronic lymphocytic leukemia ( 28165464) HDL cholesterol ( 21909109) High density lipoprotein cholesterol levels ( 30718733) Hypertension ( 32709000) Low HDL-cholesterol levels ( 31006500) Myocardial infarction ( 30226566) Response to fenofibrate (adiponectin levels) ( 23149075) Right-sided colonic diverticulosis ( 31089239)	Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		5 interacting genes: DHX30 EIF6 FTSJ3 IFRD2 MAVS	7 interacting genes: APP JRK MDFI NEDD4L OAS3 OGT POT1
Entrez ID		4940	7866
HPRD ID		04519	04101
Ensembl ID		ENSG00000111331	ENSG00000214706
Uniprot IDs		Q9Y6K5	Q12894
PDB IDs		4S3N
Enriched GO Terms of Interacting Partners?
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Tagcloud (Intersection) ?