OAS3 and FTSJ3

Number of citations of the paper that reports this interaction (PubMedID 21903422)
143

Data Source:
BioGRID (affinity chromatography technology, pull down)

		OAS3	FTSJ3
Description		2'-5'-oligoadenylate synthetase 3	FtsJ RNA 2'-O-methyltransferase 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Intracellular Membrane-bounded Organelle	Nucleoplasm Chromosome Nucleolus Preribosome, Large Subunit Precursor Preribosome, Small Subunit Precursor
	Molecular Function	2'-5'-oligoadenylate Synthetase Activity Double-stranded RNA Binding Protein Binding ATP Binding Metal Ion Binding	RNA Binding Protein Binding RNA Methyltransferase Activity RRNA (uridine-2'-O-)-methyltransferase Activity RRNA (guanine) Methyltransferase Activity RNA 2'-O-methyltransferase Activity
	Biological Process	Nucleobase-containing Compound Metabolic Process Response To Virus Positive Regulation Of Interferon-beta Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Chemokine (C-X-C Motif) Ligand 9 Production RIG-I Signaling Pathway MDA-5 Signaling Pathway Defense Response To Bacterium Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Negative Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Ribonuclease Activity Positive Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Negative Regulation Of IP-10 Production Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Enzyme-directed RRNA 2'-O-methylation Maturation Of LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RNA Methylation RRNA Methylation
Pathways		Interferon gamma signaling OAS antiviral response Interferon alpha/beta signaling	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Alcohol consumption ( 21270382) Alcohol consumption (drinkers vs non-drinkers) ( 28485404) Body mass index ( 26426971) Chronic lymphocytic leukemia ( 28165464) HDL cholesterol ( 21909109) High density lipoprotein cholesterol levels ( 30718733) Hypertension ( 32709000) Low HDL-cholesterol levels ( 31006500) Myocardial infarction ( 30226566) Response to fenofibrate (adiponectin levels) ( 23149075) Right-sided colonic diverticulosis ( 31089239)	Hemoglobin levels ( 32327693)
Interacting Genes		5 interacting genes: DHX30 EIF6 FTSJ3 IFRD2 MAVS	9 interacting genes: CSNK2A1 EIF2AK2 FANCG MAGEB4 OAS3 OGT SAT1 SSX2 SSX2B
Entrez ID		4940	117246
HPRD ID		04519	17024
Ensembl ID		ENSG00000111331	ENSG00000108592
Uniprot IDs		Q9Y6K5	Q8IY81
PDB IDs		4S3N
Enriched GO Terms of Interacting Partners?
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