MAN2A1 and SEC23B

Number of citations of the paper that reports this interaction (PubMedID 9472029)
101

Data Source:
BioGRID (unspecified method)

		MAN2A1	SEC23B
Description		mannosidase alpha class 2A member 1	SEC23 homolog B, COPII coat complex component
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Medial Cisterna Cis-Golgi Network Membrane Integral Component Of Membrane Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Endomembrane System COPII Vesicle Coat Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site
	Molecular Function	Alpha-mannosidase Activity Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase Activity Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Carbohydrate Binding Protein Homodimerization Activity Metal Ion Binding	GTPase Activator Activity Protein Binding Zinc Ion Binding
	Biological Process	In Utero Embryonic Development Liver Development Mannose Metabolic Process Protein Glycosylation N-glycan Processing Protein Deglycosylation Mitochondrion Organization Vacuole Organization Respiratory Gaseous Exchange By Respiratory System Viral Protein Processing Lung Alveolus Development Positive Regulation Of Neurogenesis Retina Morphogenesis In Camera-type Eye	Intracellular Protein Transport Regulation Of Catalytic Activity COPII-coated Vesicle Cargo Loading
Pathways		Intra-Golgi traffic Maturation of spike protein Reactions specific to the complex N-glycan synthesis pathway
Drugs		Tridolgosir 2-deoxy-2-fluoro-alpha-D-mannosyl fluoride Ghavamiol Kifunensine 5-fluoro-beta-L-gulosyl fluoride 5-Thio-a/B-D-Mannopyranosylamine 1-deoxymannojirimycin (1R,2R,3R,4S,5R)-4-(BENZYLAMINO)-5-(METHYLTHIO)CYCLOPENTANE-1,2,3-TRIOL (1S,2S,3R,6R)-4-(hydroxymethyl)-6-(octylamino)cyclohex-4-ene-1,2,3-triol
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Autism spectrum disorder or schizophrenia ( 28540026) Exploratory eye movement dysfunction in schizophrenia (cognitive search score) ( 26242244) Exploratory eye movement dysfunction in schizophrenia (number of eye fixations) ( 26242244) Exploratory eye movement dysfunction in schizophrenia (responsive search score) ( 26242244) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels in HIV infection ( 33109212) Intelligence (MTAG) ( 29326435) Number of sexual partners ( 30643258) Schizophrenia ( 28991256 25056061 29483656 30285260) Triglyceride levels ( 34074324)	Refractive error ( 32231278)
Interacting Genes		3 interacting genes: APC EPB41L4A-AS1 SEC23B	26 interacting genes: CPSF7 DTX2 FATE1 FBXW5 GALNT1 HOXA3 KDELR1 MAN2A1 NINL PRRC1 RIN1 SEC23A SEC24C SEC24D SKP1 SNRPC SRPK1 SRPK2 SYNE4 TMED1 TMED10 TMED2 TMED9 TRIM55 TRIM63 UGT1A1
Entrez ID		4124	10483
HPRD ID		01110	11543
Ensembl ID		ENSG00000112893	ENSG00000101310
Uniprot IDs		Q16706	A0A2R8YFH5 Q15437
PDB IDs
Enriched GO Terms of Interacting Partners?
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