SMAD5 and MBD1

Number of citations of the paper that reports this interaction (PubMedID 15231748)
99

Data Source:
HPRD (two hybrid)

		SMAD5	MBD1
Description		SMAD family member 5	methyl-CpG binding domain protein 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex SMAD Protein Complex Heteromeric SMAD Protein Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Nuclear Speck
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding DEAD/H-box RNA Helicase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding I-SMAD Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Methyl-CpG Binding Double-stranded Methylated DNA Binding Unmethylated CpG Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Mullerian Duct Regression Osteoblast Fate Commitment Cardiac Conduction System Development Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Anatomical Structure Morphogenesis Embryonic Pattern Specification Cell Differentiation Erythrocyte Differentiation BMP Signaling Pathway Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Cartilage Development Cardiac Muscle Contraction Bone Development SMAD Protein Signal Transduction Cellular Response To Organic Cyclic Compound Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus	Transcription By RNA Polymerase II Heart Development Aging Response To Xenobiotic Stimulus Negative Regulation Of Gene Expression Neuron Differentiation Response To Nutrient Levels Response To Estradiol Response To Cocaine Regulation Of DNA Methylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Astrocyte Differentiation
Pathways		Signaling by BMP	SUMOylation of transcription cofactors
Drugs
Diseases
GWAS		Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Mean platelet volume ( 32888494) Sleep duration (short sleep) ( 30846698)	Chronic lymphocytic leukemia ( 28165464)
Interacting Genes		46 interacting genes: ACVR1 ANKRD13A BCAT1 BMP6 CHMP3 COPS5 CXXC5 EP300 FLNA GDF6 HBG2 HGS HOXA13 HOXD13 MBD1 MEN1 MTMR10 NEDD4 PLEKHO1 PNKP POU6F2 PPIL4 PSMD11 PTPN12 RBM4 RYR2 SF3B1 SF3B3 SFPQ SMAD1 SMAD4 SMURF1 SMURF2 SNRNP70 SNRPA SOX5 SOX7 SUV39H1 SUV39H2 TOB1 U2AF2 UBA1 WBP2 WWP1 ZEB2 ZNF8	45 interacting genes: APP ATF7IP ATF7IP2 ATXN1L C1QBP CBX4 CBX5 CCDC136 CHAF1A COPE DVL3 ECT2 EEF1G GRN HDAC3 HIPK3 HTT JAG2 LTBP3 LTBP4 MDFI MEGF6 NELL1 NELL2 NOTCH1 NOTCH3 OASL PIAS1 PIAS2 POMGNT1 RNF2 SETDB1 SLC25A3 SMAD1 SMAD3 SMAD5 SMAD7 SMAD9 SNAPC2 SP1 SUV39H1 TENM1 TNC ZNF384 ZNF512B
Entrez ID		4090	4152
HPRD ID		04381	01133
Ensembl ID		ENSG00000113658	ENSG00000141644
Uniprot IDs		Q68DB7 Q99717	A8K654 B4DI41 B4DUR3 Q9UIS9
PDB IDs		6FZS 6TCE	1D9N 1IG4 4D4W 5W9Q 6D1T
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?