LCP2 and BLNK

Number of citations of the paper that reports this interaction (PubMedID 9697839)
128

Data Source:
HPRD (in vivo, in vitro)

		LCP2	BLNK
Description		lymphocyte cytosolic protein 2	B cell linker
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cell-cell Junction TCR Signalosome Plasma Membrane Raft	Cytoplasm Cytosol Plasma Membrane Membrane Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Protein Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Enzyme Binding Protein Kinase Binding Signaling Adaptor Activity SH2 Domain Binding Phospholipase Binding Protein Tyrosine Kinase Binding
	Biological Process	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction Mast Cell Activation Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway	Inflammatory Response Humoral Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Gene Expression B Cell Differentiation Intracellular Signal Transduction B Cell Receptor Signaling Pathway
Pathways		GPVI-mediated activation cascade Generation of second messenger molecules Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization	Regulation of signaling by CBL Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)	Mean spheric corpuscular volume ( 32888494)
Interacting Genes		50 interacting genes: APP BLNK CBL CD22 CLNK EGFR ELOVL6 ERBB2 ERBB3 ERBB4 FXR2 FYB1 FYN GALNT10 GOLGA2 GRAP2 GRB2 HCK ITK LARP1 LAT LCK LMNA LNX1 LYN MAP4K1 NCK1 NCK2 PAG1 PJA1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SH3RF1 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAE YWHAZ ZAP70	25 interacting genes: AR BTK CBL CBLB CD72 CD79A CMTM3 CRKL EGFR ERBB2 ERBB3 GAB1 GRAP2 GRB2 ITK KIT LCP2 MAP4K1 NCK1 PLCG1 PLCG2 PTPN6 SH3KBP1 SYK VAV1
Entrez ID		3937	29760
HPRD ID		03362	05153
Ensembl ID		ENSG00000043462	ENSG00000095585
Uniprot IDs		Q13094	Q2MD54 Q2MD59 Q8WV28
PDB IDs		1H3H 1YWO 2EAP 2ROR
Enriched GO Terms of Interacting Partners?
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