LCP2 and ELOVL6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LCP2	ELOVL6
Description		lymphocyte cytosolic protein 2	ELOVL fatty acid elongase 6
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cell-cell Junction TCR Signalosome Plasma Membrane Raft	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Fatty Acid Elongase Complex Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding	Protein Binding Fatty Acid Elongase Activity 3-oxo-arachidoyl-CoA Synthase Activity 3-oxo-cerotoyl-CoA Synthase Activity 3-oxo-lignoceronyl-CoA Synthase Activity Very-long-chain 3-ketoacyl-CoA Synthase Activity
	Biological Process	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction Mast Cell Activation Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway	Unsaturated Fatty Acid Biosynthetic Process Fatty Acid Elongation, Saturated Fatty Acid Sphingolipid Biosynthetic Process Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongation, Polyunsaturated Fatty Acid Long-chain Fatty-acyl-CoA Biosynthetic Process Long-chain Fatty Acid Biosynthetic Process Very Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of Cold-induced Thermogenesis
Pathways		GPVI-mediated activation cascade Generation of second messenger molecules Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization	Activation of gene expression by SREBF (SREBP) Synthesis of very long-chain fatty acyl-CoAs
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)	Attention deficit hyperactivity disorder ( 20732626) Benign prostatic hyperplasia ( 30988330) Depressive symptoms x dependent stressful life events interaction (1df test) ( 30718454) Liver enzyme levels (alkaline phosphatase) ( 33972514) Obesity-related traits ( 23251661) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 33031748)
Interacting Genes		50 interacting genes: APP BLNK CBL CD22 CLNK EGFR ELOVL6 ERBB2 ERBB3 ERBB4 FXR2 FYB1 FYN GALNT10 GOLGA2 GRAP2 GRB2 HCK ITK LARP1 LAT LCK LMNA LNX1 LYN MAP4K1 NCK1 NCK2 PAG1 PJA1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SH3RF1 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAE YWHAZ ZAP70	3 interacting genes: HMOX1 LCP2 RTP2
Entrez ID		3937	79071
HPRD ID		03362	13269
Ensembl ID		ENSG00000043462	ENSG00000170522
Uniprot IDs		Q13094	A1LV06 Q9H5J4
PDB IDs		1H3H 1YWO 2EAP 2ROR
Enriched GO Terms of Interacting Partners?
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