INCA1 and METAP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		INCA1	METAP1
Description		inhibitor of CDK, cyclin A1 interacting protein 1	methionyl aminopeptidase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body	Cytoplasm Cytosol
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Cyclin Binding Identical Protein Binding Protein-containing Complex Binding	Aminopeptidase Activity Protein Binding Metalloexopeptidase Activity Metal Ion Binding Metalloaminopeptidase Activity
	Biological Process	Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Apoptotic Signaling Pathway	Regulation Of Translation Proteolysis Peptidyl-methionine Modification N-terminal Protein Amino Acid Modification Protein Initiator Methionine Removal Platelet Aggregation
Pathways			Inactivation, recovery and regulation of the phototransduction cascade
Drugs			Ovalicin 5-CHLORO-6-METHYL-N-(2-PHENYLETHYL)-2-PYRIDIN-2-YLPYRIMIDIN-4-AMINE TERT-BUTYL {2-[(1,3-THIAZOL-2-YLAMINO)CARBONYL]PYRIDIN-3-YL}CARBAMATE 3-[(2,2-DIMETHYLPROPANOYL)AMINO]-N-1,3-THIAZOL-2-YLPYRIDINE-2-CARBOXAMIDE
Diseases
GWAS		Intraocular pressure ( 29235454) Keratoconus ( 33649486) Obesity-related traits ( 23251661)	Alcohol consumption (drinks per week) ( 30643258) Alcohol dependence ( 33290381) Alcohol use disorder (consumption score) ( 30336701) Alcohol use disorder (dependence and problematic use scores) ( 30336701) Alcohol use disorder (total score) ( 30336701) Oral cavity and pharyngeal cancer ( 27749845) Regular attendance at a pub or social club ( 29970889)
Interacting Genes		236 interacting genes: ABI2 ACY3 AKAP8L ANKRD28 ARMC7 ASPSCR1 ATG5 ATP6V0D2 ATPAF2 BAG3 BANF2 BOLA3 BPIFA1 C10orf55 C19orf54 C1orf35 C1orf50 C1orf56 C22orf39 CABP5 CCBE1 CCDC57 CCDC78 CCNA1 CDA CDC23 CDK18 CDK2 CDK4 CDKN1A CDKN2B CDKN2D CEP72 CHCHD2 CHCHD5 CHRD CINP CKS1B CLIC3 CLK3 COL8A1 CPSF1 CSDC2 CSTF2 CTNNBIP1 CTTNBP2 CYSRT1 DAZAP2 DEF6 DMRT3 DMRTB1 DOK4 DPH7 DUSP13 EFEMP2 EMD EPHB6 EXOSC8 FAAP20 FAIM FEM1A FGF16 FHL2 FMR1 FRS3 GEM GEMIN2 GRB2 GRXCR1 GSTO2 GTF2H5 GTPBP3 GYS1 HAUS1 HCK HDAC4 HEMK1 HENMT1 HNRNPF HOMER3 HOXA1 HR HSD17B14 HYI IL36RN ILF2 KCTD7 KCTD9 KIAA1217 KIR2DL4 KLHL26 KLHL42 KRT33B KRT5 KRT75 KRTAP15-1 KRTAP19-1 KRTAP19-5 KRTAP19-6 KRTAP5-6 KRTAP6-2 KRTAP6-3 KRTAP9-3 LENG8 LGALS3 LHX3 LMNTD2 LMO2 LMO3 LSM3 LYPLA2 MAD2L2 MAGED4B MAGOHB MALSU1 MARF1 MARK1 MATN3 MBLAC1 METAP1 MPP1 MSRB1 MTMR9 NATD1 NCK2 NDUFAF3 NEDD9 NEIL2 NEK6 NFKBID NHSL2 NME7 NMRK1 NPAS2 NTAQ1 NUBP2 NUDT16L1 NUDT22 OR6B1 OSGIN1 PADI3 PATE1 PCSK5 PCYT2 PDP1 PEF1 PFDN5 PHF1 PLA2G10 PLSCR3 POLR1C POLR3C POP5 POU4F2 PPP1R32 PRPH PSMB2 PSMB8 PTGER3 R3HDM2 RAB5C RALB RAMAC RBPMS RECK RFC3 RIPPLY3 RNF26 SAP18 SCNM1 SEC14L4 SHFL SLC22A18AS SMG9 SMUG1 SNRPB SPAG8 SPG21 SPOUT1 SPRY1 STAMBPL1 STK16 STT3B SUOX TBC1D7 TCL1A TEAD4 TEKT4 TEX12 TFAP2A TFAP2D TFAP4 TFG THAP6 THRSP TIAL1 TPRX1 TRAPPC2 TRAPPC2B TRAPPC6A TRIB3 TRIM26 TRIM55 TRIM63 TRIM68 TRIP13 TRIP6 TSEN15 TSG101 TSSK3 TSTD2 TXNDC17 UBASH3B UBE2D4 UBE2Z UBTD2 UBXN2B UFM1 UFSP1 VEZF1 VGLL3 VPS26C VPS28 WWOX YIPF3 YOD1 ZDHHC24 ZFAND3 ZMYND12 ZMYND19 ZNF205-AS1 ZNF32 ZNF446 ZNF747 ZNF765 ZNRD2	7 interacting genes: GLRX3 INCA1 MEOX2 NBR1 PLEKHG4 SMAD9 ZRANB1
Entrez ID		388324	23173
HPRD ID		17150	10071
Ensembl ID		ENSG00000196388	ENSG00000164024
Uniprot IDs		Q0VD86	P53582
PDB IDs			2B3H 2B3K 2B3L 2G6P 2GZ5 2NQ6 2NQ7 4FLI 4FLJ 4FLK 4FLL 4HXX 4IKR 4IKS 4IKT 4IKU 4IU6 4U1B 4U69 4U6C 4U6E 4U6J 4U6W 4U6Z 4U70 4U71 4U73 4U75 4U76 5YKP 5YR4 5YR5 5YR6 5YR7 6LZB 6LZC
Enriched GO Terms of Interacting Partners?
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