METAP1 and PLEKHG4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		METAP1	PLEKHG4
Description		methionyl aminopeptidase 1	pleckstrin homology and RhoGEF domain containing G4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytosol
	Molecular Function	Aminopeptidase Activity Protein Binding Metalloexopeptidase Activity Metal Ion Binding Metalloaminopeptidase Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Regulation Of Translation Proteolysis Peptidyl-methionine Modification N-terminal Protein Amino Acid Modification Protein Initiator Methionine Removal Platelet Aggregation	Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Inactivation, recovery and regulation of the phototransduction cascade	RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs		Ovalicin 5-CHLORO-6-METHYL-N-(2-PHENYLETHYL)-2-PYRIDIN-2-YLPYRIMIDIN-4-AMINE TERT-BUTYL {2-[(1,3-THIAZOL-2-YLAMINO)CARBONYL]PYRIDIN-3-YL}CARBAMATE 3-[(2,2-DIMETHYLPROPANOYL)AMINO]-N-1,3-THIAZOL-2-YLPYRIDINE-2-CARBOXAMIDE
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Alcohol dependence ( 33290381) Alcohol use disorder (consumption score) ( 30336701) Alcohol use disorder (dependence and problematic use scores) ( 30336701) Alcohol use disorder (total score) ( 30336701) Oral cavity and pharyngeal cancer ( 27749845) Regular attendance at a pub or social club ( 29970889)	Blood protein levels ( 29875488 28240269) Body shape index ( 34021172) Heel bone mineral density ( 28869591) High density lipoprotein cholesterol levels ( 33339817) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		7 interacting genes: GLRX3 INCA1 MEOX2 NBR1 PLEKHG4 SMAD9 ZRANB1	66 interacting genes: A1CF ARHGEF5 ARMC7 BEX2 CCDC120 CCDC187 CDC42 CDKN2C CHIC2 COIL DCUN1D5 DPPA3 DTX2 DUSP13 FAM161A FGD2 GATA3 GCM2 GSTZ1 HCK HOXB9 HOXC8 KRT3 KRT75 MALSU1 MATR3 MDFI METAP1 MSRB3 MTA1 MYEF2 MYOZ1 NATD1 OTX1 PFKFB1 PKP2 PLA2G15 PPP1R32 PRPF18 PRPF31 PSMB1 RHOA RIN1 SAXO1 SETD5 SH2D4A SHISA6 SIX1 SMCP SMG9 TBC1D22B TBX18 TEKT3 TENT5D TFAP2D TFG TRIM55 TRIM63 TSSK3 TTC23 USP2 VPS37C ZCCHC14 ZNF148 ZNF319 ZNF648
Entrez ID		23173	25894
HPRD ID		10071	10890
Ensembl ID		ENSG00000164024	ENSG00000196155
Uniprot IDs		P53582	A0A024R6X4 Q58EX7
PDB IDs		2B3H 2B3K 2B3L 2G6P 2GZ5 2NQ6 2NQ7 4FLI 4FLJ 4FLK 4FLL 4HXX 4IKR 4IKS 4IKT 4IKU 4IU6 4U1B 4U69 4U6C 4U6E 4U6J 4U6W 4U6Z 4U70 4U71 4U73 4U75 4U76 5YKP 5YR4 5YR5 5YR6 5YR7 6LZB 6LZC
Enriched GO Terms of Interacting Partners?
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