JUN and MYOD1

Number of citations of the paper that reports this interaction (PubMedID 1310896)
118

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vitro, in vivo)

		JUN	MYOD1
Description		Jun proto-oncogene, AP-1 transcription factor subunit	myogenic differentiation 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Plasma Membrane Transcription Factor AP-1 Complex	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Myofibril
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity RNA Binding GTPase Activator Activity Protein Binding Transcription Factor Binding Enzyme Binding Ubiquitin Protein Ligase Binding CAMP Response Element Binding Identical Protein Binding Ubiquitin-like Protein Ligase Binding Protein-containing Complex Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding R-SMAD Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Nuclear Receptor Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Release Of Cytochrome C From Mitochondria Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Ras Protein Signal Transduction Aging Learning Circadian Rhythm Response To Radiation Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Lipopolysaccharide Response To Cytokine Cellular Response To Reactive Oxygen Species Regulation Of Cell Population Proliferation Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Positive Regulation Of Neuron Apoptotic Process Negative Regulation By Host Of Viral Transcription Positive Regulation By Host Of Viral Transcription Positive Regulation Of Monocyte Differentiation Positive Regulation Of DNA Replication Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Catalytic Activity Cellular Response To Potassium Ion Starvation Response To CAMP Regulation Of Cell Cycle Membrane Depolarization SMAD Protein Signal Transduction Cellular Response To Cadmium Ion Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of DNA-templated Transcription, Initiation	Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Muscle Organ Development Myoblast Fate Determination Skeletal Muscle Tissue Development Myoblast Fusion Cellular Response To Starvation Myotube Cell Development Myotube Differentiation Involved In Skeletal Muscle Regeneration Negative Regulation Of Chromatin Binding Skeletal Muscle Cell Differentiation Muscle Cell Fate Commitment Positive Regulation Of Skeletal Muscle Tissue Regeneration Regulation Of RNA Splicing Skeletal Muscle Fiber Adaptation Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Fiber Development Positive Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Binding Positive Regulation Of Muscle Cell Differentiation Cellular Response To Tumor Necrosis Factor Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Oxygen Levels Positive Regulation Of Myoblast Fusion Positive Regulation Of SnRNA Transcription By RNA Polymerase II Negative Regulation Of Myoblast Proliferation
Pathways		Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) FCERI mediated MAPK activation Activation of the AP-1 family of transcription factors Activation of anterior HOX genes in hindbrain development during early embryogenesis MAPK6/MAPK4 signaling TP53 Regulates Transcription of DNA Repair Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Regulation of PTEN gene transcription Regulation of PTEN gene transcription Estrogen-dependent gene expression WNT5:FZD7-mediated leishmania damping	Myogenesis Myogenesis
Drugs		Adapalene Vinblastine Pseudoephedrine Irbesartan Arsenic trioxide LGD-1550
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Cognitive performance ( 19734545) Night sleep phenotypes ( 27126917)	Body mass index ( 26426971) Hodgkin's lymphoma ( 34216518) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)
Interacting Genes		189 interacting genes: ABL1 AKAP5 APLP2 APP AR ARRB1 ATF1 ATF2 ATF3 ATF4 BATF BATF2 BBS7 BCL3 BCL6 BLM BRCA1 CASP9 CCND1 CEBPE CEBPG CLINT1 COP1 COPS5 CREB3 CREB5 CREBBP CSNK2A1 DAB1 DACH1 DDIT3 DDX21 DHX9 DNMT3L EDF1 EGR1 ELF3 ELOF1 EN1 EP300 EPAS1 ERG ESR1 ETS1 ETS2 ETV1 ETV4 EWSR1 FBXW7 FOS FOSB FOSL1 FOSL2 GART GATA2 GOPC GPR18 GSK3B GTF2B GTF2E2 GTF2F1 GTF2F2 HCFC1 HDAC3 HDAC9 HDGF HHEX HIF1A HMGA1 HNRNPM HOXA9 HOXC8 HSP90AA1 HSPA8 IKBKB IRAK1 ISCU ITCH ITPK1 JDP2 KLF5 KMT2C KPNA2 M6PR MACF1 MAF MAFB MAP2K4 MAP2K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MAPKAPK5 MAPRE3 MBD3 MDM2 MOK MTA1 MYBBP1A MYOD1 NACA NAT14 NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NEDD4 NELFB NFE2L1 NFE2L2 NFYA NFYC NR3C1 NR5A1 NRIP1 NTRK3 PACS1 PHOX2A PIAS1 PIAS2 PIN1 PML POU1F1 PPARG PPP3CB PPP4C PRKD1 PRKDC PRRC2A RB1 RBM39 RELA RNF187 ROR1 RPL18A RPS6KA2 RUNX1 RUNX2 SKI SMAD2 SMAD3 SMAD4 SMARCD1 SMARCD3 SNAPC5 SNIP1 SNRK SOX10 SOX8 SP1 SPI1 SPIB STAT1 STAT3 STAT4 STRN4 SUMO1 SUMO2 SUMO3 SUMO4 TACSTD2 TAF1 TAF4 TBP TCF20 TCF4 TDG TGIF1 TOP1 TOP2A TP53 TPM1 TPM2 TRAF2 TRIP4 TSC22D3 TSG101 UBB UBC UBE2I USP6 VAV1 VDR ZBTB7C	67 interacting genes: AP1M1 ASCL3 BHLHA15 BHLHE40 BHLHE41 C2orf88 CALM1 CALM2 CALM3 CARM1 CDC34 CDK2 CDK4 CDKN1C CIB2 CREBBP CSRP3 ELSPBP1 EP300 EXOC3L1 FBXO32 FIGLA HAND1 HDAC1 HEY1 HSP90AA1 ID1 ID2 ID3 ID4 IFRD1 IGFN1 JUN KAT2B KAT5 KPNA3 LMO4 MDFI MEF2A MEF2C MOS MYOCD NCOR1 NCOR2 NR2F2 PHB2 POLR2G PRKCA PRMT5 PSMD4 PSME2 RB1 RORA RUNX1 RXRA SETD3 SMAD3 SMAD4 SMAD7 SP1 SRF STAT3 SUV39H1 TCF21 TCF3 TCF4 TWIST1
Entrez ID		3725	4654
HPRD ID		01302	01166
Ensembl ID		ENSG00000177606	ENSG00000129152
Uniprot IDs		P05412	P15172
PDB IDs		1A02 1FOS 1JNM 1JUN 1S9K 1T2K 5FV8 5T01 6Y3V
Enriched GO Terms of Interacting Partners?
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