MYOD1 and TCF21

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		MYOD1	TCF21
Description		myogenic differentiation 1	transcription factor 21
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Myofibril	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Nuclear Receptor Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Histone Deacetylase Binding BHLH Transcription Factor Binding Protein Dimerization Activity Androgen Receptor Binding E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Muscle Organ Development Myoblast Fate Determination Skeletal Muscle Tissue Development Myoblast Fusion Cellular Response To Starvation Myotube Cell Development Myotube Differentiation Involved In Skeletal Muscle Regeneration Negative Regulation Of Chromatin Binding Skeletal Muscle Cell Differentiation Muscle Cell Fate Commitment Positive Regulation Of Skeletal Muscle Tissue Regeneration Regulation Of RNA Splicing Skeletal Muscle Fiber Adaptation Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Fiber Development Positive Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Binding Positive Regulation Of Muscle Cell Differentiation Cellular Response To Tumor Necrosis Factor Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Oxygen Levels Positive Regulation Of Myoblast Fusion Positive Regulation Of SnRNA Transcription By RNA Polymerase II Negative Regulation Of Myoblast Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Morphogenesis Of A Branching Structure Kidney Development Vasculature Development Regulation Of Transcription By RNA Polymerase II Sex Determination Branchiomeric Skeletal Muscle Development Epithelial Cell Differentiation Developmental Process Glomerulus Development Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Spleen Development Embryonic Digestive Tract Morphogenesis Reproductive Structure Development Gland Development Sertoli Cell Differentiation Roof Of Mouth Development Lung Morphogenesis Lung Vasculature Development Bronchiole Development Diaphragm Development Respiratory System Development Negative Regulation Of Androgen Receptor Signaling Pathway Metanephric Mesenchymal Cell Differentiation Metanephric Glomerular Capillary Formation
Pathways		Myogenesis Myogenesis
Drugs
Diseases
GWAS		Body mass index ( 26426971) Hodgkin's lymphoma ( 34216518) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)	Blood pressure traits (multi-trait analysis) ( 28498854) Blood urea nitrogen levels ( 31152163) Coronary artery disease ( 32469254 29212778 24262325 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 22751097 21378990) Diastolic blood pressure ( 28498854) Haemorrhoidal disease ( 33888516) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) PR interval ( 32439900) Pulse pressure ( 28498854) Systolic blood pressure ( 28498854)
Interacting Genes		67 interacting genes: AP1M1 ASCL3 BHLHA15 BHLHE40 BHLHE41 C2orf88 CALM1 CALM2 CALM3 CARM1 CDC34 CDK2 CDK4 CDKN1C CIB2 CREBBP CSRP3 ELSPBP1 EP300 EXOC3L1 FBXO32 FIGLA HAND1 HDAC1 HEY1 HSP90AA1 ID1 ID2 ID3 ID4 IFRD1 IGFN1 JUN KAT2B KAT5 KPNA3 LMO4 MDFI MEF2A MEF2C MOS MYOCD NCOR1 NCOR2 NR2F2 PHB2 POLR2G PRKCA PRMT5 PSMD4 PSME2 RB1 RORA RUNX1 RXRA SETD3 SMAD3 SMAD4 SMAD7 SP1 SRF STAT3 SUV39H1 TCF21 TCF3 TCF4 TWIST1	10 interacting genes: APEX1 APLP1 GTF3C5 HOXB6 KLF15 LMO4 MYOD1 SDCBP TCF12 TCF3
Entrez ID		4654	6943
HPRD ID		01166	04493
Ensembl ID		ENSG00000129152	ENSG00000118526
Uniprot IDs		P15172	O43680
PDB IDs
Enriched GO Terms of Interacting Partners?
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