INPP5D and LILRB4

Number of citations of the paper that reports this interaction (PubMedID 9422771)
5

Data Source:
HPRD (in vitro)

		INPP5D	LILRB4
Description		inositol polyphosphate-5-phosphatase D	leukocyte immunoglobulin like receptor B4
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GO Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane Membrane Raft	Plasma Membrane Cell Surface Extracellular Exosome Integral Component Of The Cytoplasmic Side Of The Plasma Membrane
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity SH3 Domain Binding Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity	Protein Binding Protein Phosphatase Binding Transmembrane Receptor Protein Tyrosine Kinase Inhibitor Activity Signaling Receptor Inhibitor Activity
	Biological Process	Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Apoptotic Process Signal Transduction Determination Of Adult Lifespan Negative Regulation Of Signal Transduction Immunoglobulin Mediated Immune Response Negative Regulation Of B Cell Proliferation Negative Regulation Of Interleukin-6 Production Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Monocyte Differentiation Negative Regulation Of Neutrophil Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Bone Resorption Phosphatidylinositol Dephosphorylation Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway	Adaptive Immune Response Tolerance Induction Positive Regulation Of T Cell Anergy Negative Regulation Of T Cell Cytokine Production Fc Receptor Mediated Inhibitory Signaling Pathway Receptor Internalization Negative Regulation Of Chemokine Production Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-5 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of T Cell Proliferation Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Negative Regulation Of MAPK Cascade Negative Regulation Of Cytotoxic T Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of IP-10 Production Interleukin-10-mediated Signaling Pathway Negative Regulation Of Monocyte Activation Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Signaling Receptor Activity Negative Regulation Of T Cell Costimulation
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Downstream TCR signaling PECAM1 interactions Interleukin receptor SHC signaling	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Contrast sensitivity ( 24152035) Crohn's disease ( 22412388 23128233) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Family history of Alzheimer's disease ( 30617256) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Perceived unattractiveness to mosquitoes ( 28199695) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Serum alkaline phosphatase levels ( 33547301) Sum eosinophil basophil counts ( 27863252)	Blood protein levels ( 28240269) Clozapine-induced agranulocytosis ( 25187353) Inflammatory bowel disease ( 23128233) Response to platinum-based chemotherapy (carboplatin) ( 21844884)
Interacting Genes		46 interacting genes: ARAP1 CD22 CD300LF CRKL CSF1R CSF3R CYSRT1 DAB1 DAB2 DOK1 DOK2 DOK3 EPOR FCGR1B FCGR2B FGR FLT3 GAB1 GAB2 GRB2 HCK IL4R JAK1 JAK3 KHDRBS3 KIT KRT31 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP6-3 LILRB4 LYN MET NOTCH2NLA PAX6 PECAM1 PLCG1 PTPN11 SH3KBP1 SHC1 SLAMF1 XIAP ZDHHC17	3 interacting genes: INPP5D PTPN11 PTPN6
Entrez ID		3635	11006
HPRD ID		09033	11996
Ensembl ID		ENSG00000168918	ENSG00000186818
Uniprot IDs		Q92835	A0A0A0MSZ8 Q8NHJ6
PDB IDs		2YSX 5RW2 5RW3 5RW4 5RW5 5RW6 5RW7 5RW8 5RW9 5RWA 5RWB 5RWC 5RWD 5RWE 5RWF 5RWG 5RWH 5RWI 5RWJ 5RWK 5RWL 5RWM 5RWN 5RWO 5RWP 5RWQ 5RWR 5RWS 5RWT 5RWU 5RWV 5RWW 5RWX 5RWY 5RWZ 5RX0 5RX1 5RX2 5RX3 5RX4 5RX5 5RX6 5RX7 5RX8 5RX9 5RXA 5RXB 5RXC 5RXD 5RXE 5RXF 5RXG 5RXH 5RXI 5RXJ 5RXK 5RXL 5RXM 5RXO 5RXP 5RXQ 5RXR 5RXS 5RXT 5RXU 5RXV 5RXW 5RXX 5RXY 5RXZ 5RY0 5RY1 5RY2 5RY3 5RY4 5RY5 5RY6 5RY7 5RY8 5RY9 5RYA 5RYB 5RYC 5RYD 5RYE 5RYF 5RYG 5RYH 5RYI 5RYJ 5RYK 5RYL 6IBD 6XY7	3P2T 6K7O
Enriched GO Terms of Interacting Partners?
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