LILRB4 and PTPN6

Number of citations of the paper that reports this interaction (PubMedID 9151699)
93

Data Source:
HPRD (in vitro)

		LILRB4	PTPN6
Description		leukocyte immunoglobulin like receptor B4	protein tyrosine phosphatase non-receptor type 6
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Extracellular Exosome Integral Component Of The Cytoplasmic Side Of The Plasma Membrane	Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cell-cell Junction Membrane Protein-containing Complex Specific Granule Lumen Alpha-beta T Cell Receptor Complex Extracellular Exosome Tertiary Granule Lumen
	Molecular Function	Protein Binding Protein Phosphatase Binding Transmembrane Receptor Protein Tyrosine Kinase Inhibitor Activity Signaling Receptor Inhibitor Activity	Phosphotyrosine Residue Binding Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding SH3 Domain Binding Protein Kinase Binding SH2 Domain Binding Cell Adhesion Molecule Binding Phosphorylation-dependent Protein Binding
	Biological Process	Adaptive Immune Response Tolerance Induction Positive Regulation Of T Cell Anergy Negative Regulation Of T Cell Cytokine Production Fc Receptor Mediated Inhibitory Signaling Pathway Receptor Internalization Negative Regulation Of Chemokine Production Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-5 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of T Cell Proliferation Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Negative Regulation Of MAPK Cascade Negative Regulation Of Cytotoxic T Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of IP-10 Production Interleukin-10-mediated Signaling Pathway Negative Regulation Of Monocyte Activation Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Signaling Receptor Activity Negative Regulation Of T Cell Costimulation	Hematopoietic Progenitor Cell Differentiation Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Protein Dephosphorylation G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Cell Differentiation Platelet Formation T Cell Costimulation Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Abortive Mitotic Cell Cycle Positive Regulation Of Cell Adhesion Mediated By Integrin Peptidyl-tyrosine Dephosphorylation Intracellular Signal Transduction Megakaryocyte Development Negative Regulation Of T Cell Proliferation Natural Killer Cell Mediated Cytotoxicity Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Regulation Of B Cell Differentiation Negative Regulation Of Peptidyl-tyrosine Phosphorylation B Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Epididymis Development Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	GPVI-mediated activation cascade Regulation of KIT signaling Signaling by ALK PECAM1 interactions Costimulation by the CD28 family PD-1 signaling Signal regulatory protein family interactions Platelet sensitization by LDL Interleukin-3, Interleukin-5 and GM-CSF signaling CD22 mediated BCR regulation Neutrophil degranulation Interferon gamma signaling Regulation of IFNG signaling Interleukin-37 signaling Interferon alpha/beta signaling Interleukin receptor SHC signaling Regulation of IFNA signaling Growth hormone receptor signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs			Tiludronic acid
Diseases
GWAS		Blood protein levels ( 28240269) Clozapine-induced agranulocytosis ( 25187353) Inflammatory bowel disease ( 23128233) Response to platinum-based chemotherapy (carboplatin) ( 21844884)	Mean corpuscular hemoglobin concentration ( 29403010) Red blood cell fatty acid levels ( 25500335) Refractive error ( 32231278)
Interacting Genes		3 interacting genes: INPP5D PTPN11 PTPN6	115 interacting genes: AATK ABL1 ACTN1 ACTN4 BCR BLNK BTLA CAV1 CBL CCDC88A CD22 CD247 CD300LF CD33 CD5 CD72 CD79A CD79B CDK1 CEACAM1 CLEC4A CSF2RB CTNNB1 CTNND1 CUZD1 CXCR4 DOK1 EGFR EPOR ERBB2 ERBB3 ERBB4 ESR1 FAS FCGR2B FCRL3 FGFR4 FHL3 FLT3 GAB2 GHR GRB2 HOXA10 IFNAR1 IGF1R IL2RB IL4R IL6ST INSR IRS2 IRS4 JAK1 JAK2 JAK3 KDR KHDRBS1 KIR2DL3 KIR2DL5A KIT KLRA1P KLRB1 KLRC1 LAIR1 LAT LCK LCP2 LIFR LILRB2 LILRB4 LMTK2 LYN MPIG6B MS4A2 MYH9 NOS1 OLIG1 PAG1 PDGFRB PECAM1 PIK3R1 PILRA PILRB PLCG2 PRKCA PRKCD PTK2B PTK7 PTPN11 PTPRC ROR1 ROR2 ROS1 SHC1 SIGLEC10 SIGLEC11 SIGLEC12 SIRPA SLAMF6 SOS1 SPATA2 SRC SSTR2 STAT5B STAT6 SYK TFG TLR10 TMEM62 TNFRSF1A TRAF3 TRAF6 TREML1 TYK2 VAV1 ZAP70
Entrez ID		11006	5777
HPRD ID		11996	01475
Ensembl ID		ENSG00000186818	ENSG00000111679
Uniprot IDs		A0A0A0MSZ8 Q8NHJ6	P29350 Q53XS4
PDB IDs		3P2T 6K7O	1FPR 1GWZ 1X6C 2B3O 2RMX 2YU7 3PS5 4GRY 4GRZ 4GS0 4HJP 4HJQ 6SM5
Enriched GO Terms of Interacting Partners?
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