LILRB4

Description		leukocyte immunoglobulin like receptor B4
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GO Annotations	Cellular Component	Plasma Membrane Cell Surface Extracellular Exosome Integral Component Of The Cytoplasmic Side Of The Plasma Membrane
	Molecular Function	Protein Binding Protein Phosphatase Binding Transmembrane Receptor Protein Tyrosine Kinase Inhibitor Activity Signaling Receptor Inhibitor Activity
	Biological Process	Adaptive Immune Response Tolerance Induction Positive Regulation Of T Cell Anergy Negative Regulation Of T Cell Cytokine Production Fc Receptor Mediated Inhibitory Signaling Pathway Receptor Internalization Negative Regulation Of Chemokine Production Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-5 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of T Cell Proliferation Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Negative Regulation Of MAPK Cascade Negative Regulation Of Cytotoxic T Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of IP-10 Production Interleukin-10-mediated Signaling Pathway Negative Regulation Of Monocyte Activation Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Signaling Receptor Activity Negative Regulation Of T Cell Costimulation
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Clozapine-induced agranulocytosis ( 25187353) Inflammatory bowel disease ( 23128233) Response to platinum-based chemotherapy (carboplatin) ( 21844884)
Interacting Genes		3 interacting genes: INPP5D PTPN11 PTPN6
Entrez ID		11006
HPRD ID		11996
Ensembl ID		ENSG00000186818
Uniprot IDs		A0A0A0MSZ8 Q8NHJ6
PDB IDs		3P2T 6K7O
Enriched GO Terms of Interacting Partners?
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