IL15RA and IL2RB

Number of citations of the paper that reports this interaction (PubMedID 7641685)
153

Data Source:
HPRD (in vitro, in vivo)

		IL15RA	IL2RB
Description		interleukin 15 receptor subunit alpha	interleukin 2 receptor subunit beta
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Endosome Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Integral Component Of Membrane Cytoplasmic Vesicle Membrane Nuclear Membrane	Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Interleukin-2 Receptor Complex External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Cytokine Receptor Activity Protein Binding Protein Kinase Binding Interleukin-15 Receptor Activity	Interleukin-2 Receptor Activity Protein Binding Interleukin-2 Binding Interleukin-15 Receptor Activity
	Biological Process	Positive Regulation Of Natural Killer Cell Differentiation Interleukin-15-mediated Signaling Pathway Positive Regulation Of Phagocytosis	Signal Transduction Cytokine-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Phagocytosis Protein-containing Complex Assembly
Pathways		Interleukin-15 signaling Interleukin-15 signaling	RAF/MAP kinase cascade Interleukin-15 signaling Interleukin-15 signaling Interleukin-2 signaling Interleukin receptor SHC signaling
Drugs			Denileukin diftitox Aldesleukin Basiliximab Daclizumab
Diseases
GWAS		Alopecia areata ( 25608926) Asthma ( 31959851 31619474) Asthma (bronchodilator response) ( 23508266) Atopic dermatitis ( 26482879) Blood protein levels ( 30072576 29875488 28240269) Diisocyanate-induced asthma ( 25918132) Inflammatory bowel disease ( 23128233) Medication use (thyroid preparations) ( 31015401) Neuroblastoma (pediatric) ( 32599975) Soluble interleukin-2 receptor subunit alpha ( 26293465)	Asthma ( 20860503 32296059) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) L-selectin levels ( 25576479) Lack of premeditation ( 30718321) Mean corpuscular volume ( 27863252) Rheumatoid arthritis ( 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Tuberculosis ( 24057671) Type 1 diabetes ( 21829393)
Interacting Genes		12 interacting genes: AXL BCL10 CASK CDK2 CDK4 IL15 IL2RB IL2RG PIAS4 RCVRN SYK TRAF2	32 interacting genes: CISH EIF3B FYN GRB2 HGS IL15 IL15RA IL2 IL2RA IL2RG JAK1 JAK3 LCK LYN MKKS MTDH ODF3B PIK3R1 PTPN6 RACK1 RAF1 SHB SHC1 SOCS1 SOCS3 SPIB STAT1 STAT3 STAT5A STAT5B SYK TRIP13
Entrez ID		3601	3560
HPRD ID		03045	00896
Ensembl ID		ENSG00000134470	ENSG00000100385
Uniprot IDs		A0A0A0MS77 G8CVM3 Q13261	P14784
PDB IDs		2ERS 2Z3Q 2Z3R 4GS7	1ILM 1ILN 2B5I 2ERJ 3QAZ 4GS7 5M5E 6E8K
Enriched GO Terms of Interacting Partners?
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