IL2RB and IL15

Number of citations of the paper that reports this interaction (PubMedID 8026467)
216

Data Source:
HPRD (in vivo)

		IL2RB	IL15
Description		interleukin 2 receptor subunit beta	interleukin 15
Image
GO Annotations	Cellular Component	Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Interleukin-2 Receptor Complex External Side Of Plasma Membrane Cell Surface Membrane	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Endosome Golgi Apparatus Cytosol Cell Surface Nuclear Speck
	Molecular Function	Interleukin-2 Receptor Activity Protein Binding Interleukin-2 Binding Interleukin-15 Receptor Activity	Cytokine Activity Cytokine Receptor Binding Protein Binding
	Biological Process	Signal Transduction Cytokine-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Phagocytosis Protein-containing Complex Assembly	Positive Regulation Of Cytokine Production NK T Cell Proliferation Inflammatory Response Immune Response Signal Transduction Tyrosine Phosphorylation Of STAT Protein Cell-cell Signaling Aging Positive Regulation Of Cell Population Proliferation Skeletal Muscle Atrophy Hyaluronan Metabolic Process Macrophage Differentiation Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Tissue Remodeling Interleukin-15-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Neutrophil Activation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Extrathymic T Cell Selection Regulation Of T Cell Differentiation Cell Maturation Lymph Node Development Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Defense Response To Virus By Host Positive Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phagocytosis Positive Regulation Of Immune Response Cellular Response To Vitamin D Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Protein O-linked Glycosylation
Pathways		RAF/MAP kinase cascade Interleukin-15 signaling Interleukin-15 signaling Interleukin-2 signaling Interleukin receptor SHC signaling	Interleukin-15 signaling Interleukin-15 signaling
Drugs		Denileukin diftitox Aldesleukin Basiliximab Daclizumab	Cefazolin
Diseases
GWAS		Asthma ( 20860503 32296059) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) L-selectin levels ( 25576479) Lack of premeditation ( 30718321) Mean corpuscular volume ( 27863252) Rheumatoid arthritis ( 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Tuberculosis ( 24057671) Type 1 diabetes ( 21829393)	Insomnia ( 29520036) Malaria ( 31844061) Post-traumatic stress disorder symptoms in trauma-exposed soldiers ( 30999091) Response to treatment for acute lymphoblastic leukemia ( 19176441)
Interacting Genes		32 interacting genes: CISH EIF3B FYN GRB2 HGS IL15 IL15RA IL2 IL2RA IL2RG JAK1 JAK3 LCK LYN MKKS MTDH ODF3B PIK3R1 PTPN6 RACK1 RAF1 SHB SHC1 SOCS1 SOCS3 SPIB STAT1 STAT3 STAT5A STAT5B SYK TRIP13	7 interacting genes: APP IL15RA IL2RB IL2RG POLR1H STAT5B TRAF3
Entrez ID		3560	3600
HPRD ID		00896	02776
Ensembl ID		ENSG00000100385	ENSG00000164136
Uniprot IDs		P14784	P40933
PDB IDs		1ILM 1ILN 2B5I 2ERJ 3QAZ 4GS7 5M5E 6E8K	2XQB 2Z3Q 2Z3R 4GS7
Enriched GO Terms of Interacting Partners?
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